SCHEMBL3359948

SCHEMBL3359948

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4CC(O)(C(=O)NCCBr)CC[C@]4(C)[C@H]3CC[C@]12C

nearest known ligand 0.60

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
USP2 O75604 2/20 0.60
CYP46A1 Q9Y6A2 2/20 0.60
LMNA P02545 1/20 0.60
ABCB1 P08183 1/20 0.60
OSBP P22059 1/20 0.60
RORC P51449 1/20 0.60
OSBP2 Q969R2 1/20 0.60
POLA1 P09884 1/20 0.57
GRIN1 Q05586 12/20 0.56
GRIN2B Q13224 12/20 0.56
GRIN2A Q12879 10/20 0.55
SRD5A1 P18405 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL998341 0.92 USP2 (0.60) USP2CYP46A1LMNAABCB1OSBP
SCHEMBL19692309 0.92 USP2 (0.60) USP2CYP46A1LMNAABCB1OSBP
SCHEMBL19691912 0.92 USP2 (0.60) USP2CYP46A1LMNAABCB1OSBP
SCHEMBL1050027 0.91 USP2 (0.59) USP2CYP46A1LMNAABCB1OSBP
SCHEMBL1081197 0.91 USP2 (0.59) USP2CYP46A1LMNAABCB1OSBP
SCHEMBL22658123 0.91 USP2 (0.59) USP2CYP46A1LMNAABCB1OSBP
SCHEMBL8205164 0.91 USP2 (0.59) USP2CYP46A1LMNAABCB1OSBP
SCHEMBL2440566 0.91 OSBP (0.58) USP2CYP46A1LMNAABCB1OSBP
Hydrochloric Acid SCHEMBL11907786 0.91 USP2 (0.58) USP2CYP46A1LMNAABCB1OSBP
SCHEMBL18797660 0.91 USP2 (0.58) USP2CYP46A1LMNAABCB1OSBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117843982-A Highly branched poly (beta-amino ester) containing cholesterol and phosphoric acid modification, synthesis method thereof and mRNA delivery application 西安交通大学 2024-04-09 CN claimed
CN-117843982-A Highly branched poly (beta-amino ester) containing cholesterol and phosphoric acid modification, synthesis method thereof and mRNA delivery application 西安交通大学 2024-04-09 CN disclosed
CN-101686940-B Method for delivering protein into cell AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2014-10-22 CN disclosed
US-8821859-B2 Methods and articles for the delivery of therapeutic agents AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2014-09-02 US disclosed
US-8425900-B2 Method of delivering a protein into a cell AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2013-04-23 US disclosed
CN-102895668-A Method of delivering a protein into a cell AGENCY SCIENCE TECH & RES 2013-01-30 CN disclosed
US-20100119501-A1 METHOD OF DELIVERING A PROTEIN INTO A CELL AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2010-05-13 US disclosed
CN-101686940-A Method for delivering protein into cell AGENCY SCIENCE TECH & RES 2010-03-31 CN disclosed
EP-1750666-A2 METHODS AND ARTICLES FOR THE DELIVERY OF THERAPEUTIC AGENTS Agency for Science, Technology and Research (SG) 2007-02-14 EP disclosed
WO-2005112886-A2 METHODS AND ARTICLES FOR THE DELIVERY OF THERAPEUTIC AGENTS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2005-12-01 WO disclosed
US-20050260276-A1 Methods and articles for the delivery of therapeutic agents AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2005-11-24 US disclosed
EP-1572029-A1 METHOD OF LOADING BENEFICIAL AGENT TO A PROSTHESIS BY FLUID-JET APPLICATION Abbott Laboratories (US) 2005-09-14 EP disclosed
WO-2004043299-A1 METHOD OF LOADING BENEFICIAL AGENT TO A PROSTHESIS BY FLUID-JET APPLICATION ABBOTT LABORATORIES (US) 2004-05-27 WO disclosed
WO-2003094971-A1 CATIONIC LIPIDS FOR INTRACELLULAR DELIVERY OF BIOACTIVE SUBSTANCES JOHNS HOPKINS SINGAPORE PTE LTD (SG) 2003-11-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050260276-A1 Methods and articles for the delivery of therapeutic agents MTREX, SNRPA, ANXA6 USP2 1573/4885CYP46A1 4170/4885LMNA 154/4885
US-20100119501-A1 METHOD OF DELIVERING A PROTEIN INTO A CELL LNPEP, ANXA6, PPHLN1 USP2 1054/4885CYP46A1 3487/4885LMNA 1233/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.