Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3354468 | 0.97 | LMNA (0.43) | LMNAHTTMAPK1HPGDL3MBTL1 | |
| SCHEMBL19697696 | 0.83 | L3MBTL1 (0.44) | LMNAHPGDL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL7428432 | 0.83 | KDM4E (0.47) | HPGDL3MBTL1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL11291506 | 0.83 | ADRB2 (0.39) | HPGDL3MBTL1KDM4ESMN1; SMN2CA1 | |
| SCHEMBL7486627 | 0.83 | KDM4E (0.39) | HPGDL3MBTL1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7429609 | 0.81 | POLB (0.40) | LMNAHPGDKDM4ESMN1; SMN2CA1 | |
| SCHEMBL7433867 | 0.81 | POLB (0.44) | LMNAHPGDKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3360919 | 0.80 | KDM4E (0.48) | LMNAHTTL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL3360173 | 0.80 | ADRA1A (0.40) | ADRA1ATAAR1 | |
| SCHEMBL16791808 | 0.80 | POLB (0.43) | LMNAHPGDKDM4ESMN1; SMN2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2189442-B1 | Process and intermediates for the preparation of aliskiren | KRKA TOVARNA ZDRAVIL D D NOVO MESTO (SI) | 2014-10-01 | — | — | EP | disclosed |
| EP-2189442-A1 | Process and intermediates for the preparation of aliskiren | Krka Tovarna Zdravil, D.D., Novo Mesto (SI) | 2010-05-26 | — | — | EP | disclosed |