Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 4/20 | 0.39 |
| ▸ | CDK4 | P11802 | 4/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | BCL6 | P41182 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361858 | 0.89 | ZAP70 (0.47) | SYKJAK2CSF1RCDK4CDK6 | |
| SCHEMBL3357921 | 0.88 | ZAP70 (0.47) | ZAP70MAP4K1PIK3CAMTOR | |
| SCHEMBL3363341 | 0.87 | SYK (0.41) | SYKCSF1RCDK4CDK6CCNK | |
| SCHEMBL3360946 | 0.84 | ZAP70 (0.51) | SYKZAP70PIK3CAMTOR | |
| SCHEMBL3361273 | 0.81 | SYK (0.43) | SYKJAK2ZAP70 | |
| SCHEMBL3356910 | 0.81 | MTOR (0.42) | SYKJAK2CSF1RCDK4CDK6 | |
| SCHEMBL3359250 | 0.80 | ZAP70 (0.53) | SYKJAK2ZAP70 | |
| SCHEMBL3362516 | 0.80 | ZAP70 (0.47) | SYKCSF1RCDK4CDK6PIK3CD | |
| SCHEMBL3362467 | 0.80 | ZAP70 (0.49) | ZAP70MAP4K1PIK3CA | |
| SCHEMBL3362632 | 0.79 | ZAP70 (0.45) | SYKJAK2ZAP70MAP4K1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |