Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 8/20 | 0.35 |
| ▸ | DRD4 | P21917 | 8/20 | 0.35 |
| ▸ | HTR1A | P08908 | 6/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362321 | 0.91 | TGFBR1 (0.35) | ZAP70DRD2DRD4HTR1ABTK | |
| SCHEMBL3361998 | 0.90 | ZAP70 (0.42) | ZAP70BTKKCNH2BRD4EML4 | |
| SCHEMBL3359006 | 0.87 | BTK (0.43) | ZAP70SYKBTKBRD4 | |
| SCHEMBL3359534 | 0.86 | ZAP70 (0.39) | SLC18A3ZAP70DRD2DRD4CSF1R | |
| SCHEMBL3360902 | 0.85 | SYK (0.39) | ZAP70HTR1ASYKBTKBRD4 | |
| SCHEMBL3362356 | 0.84 | BTK (0.38) | ZAP70SYKBTKBRD4ALK | |
| SCHEMBL3358208 | 0.82 | TLR9 (0.40) | ZAP70DRD2DRD4HTR1ABTK | |
| SCHEMBL3361810 | 0.80 | TLR9 (0.39) | ZAP70DRD2DRD4HTR1ABTK | |
| SCHEMBL3362930 | 0.79 | TLR7 (0.36) | ZAP70CSF1RSYKBTKTLR9 | |
| SCHEMBL3359920 | 0.79 | IGF1R (0.39) | ZAP70SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |