Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | CASP7 | P55210 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7307696 | 0.99 | KDM4E (0.45) | KDM4ERXFP1ALDH1A1CASP1CASP7 | |
| Fumaric Acid SCHEMBL7310330 | 0.90 | KDM4E (0.42) | KDM4ERXFP1ALDH1A1CASP1CASP7 | |
| Cadaverine Tartrate SCHEMBL7306563 | 0.89 | AOC3 (0.42) | KDM4ERXFP1ALDH1A1CASP1CASP7 | |
| SCHEMBL30903340 | 0.84 | ROCK2 (0.49) | KDM4EALDH1A1CASP1HPGDHSD17B10 | |
| SCHEMBL7285351 | 0.84 | ROCK2 (0.49) | KDM4EALDH1A1CASP1HPGDHSD17B10 | |
| SCHEMBL7282842 | 0.84 | ROCK2 (0.51) | KDM4EHPGDHSD17B10CNR2ROCK2 | |
| SCHEMBL9695411 | 0.84 | KDM4E (0.44) | KDM4ERXFP1ALDH1A1CASP1CASP7 | |
| Hydrochloric Acid SCHEMBL9696867 | 0.83 | KDM4E (0.43) | KDM4ERXFP1ALDH1A1CASP1CASP7 | |
| SCHEMBL7282646 | 0.79 | ROCK2 (0.56) | CNR2ROCK2ROCK1GRM5 | |
| SCHEMBL7291799 | 0.79 | MAPK13 (0.49) | KDM4EALDH1A1CNR2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281705-A | Precipitating from a starting material which is a solution of the starting material in an inorganic or organic acid, and precipitating with a base, or a solution of starting material in a chlorinated hydrocarbon, precipitating with hydrocarbon | ARZNEIMITTELWERK DRESDEN GMBH (DD) | 1994-01-25 | — | — | US | claimed |
| US-5204464-A | Cardiotonic agents, vasodilators | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1993-04-20 | — | — | US | claimed |
| EP-0445553-A1 | Compact crystalline 3-cyano-2-morpholino-5-(pyridyl-4)-pyridine with high bulk density and process for preparation | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1991-09-11 | — | — | EP | claimed |
| US-20100092479-A1 | Compositions and methods for treatment of viral diseases | COMBINATORX (SINGAPORE) PTE. LTD. (SG) | 2010-04-15 | — | — | US | disclosed |
| WO-2010021681-A2 | COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES | COMBINATORX (SINGAPORE) PTE. LTD. (SG) | 2010-02-25 | — | — | WO | disclosed |
| US-20100009970-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES | COMBINATORX (SINGAPORE) PTE. LTD. (SG) | 2010-01-14 | — | — | US | disclosed |
| US-20080161324-A1 | Compositions and methods for treatment of viral diseases | EXCRX (SINGAPORE) PTE. LTD. (F.K.A. COMBINATORX (SINGAPORE) PTE LTD.) (SG) | 2008-07-03 | — | — | US | disclosed |
| WO-2008033466-A2 | COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES | COMBINATORX (SINGAPORE) PRE. LTD. (SG) | 2008-03-20 | — | — | WO | disclosed |
| US-5281705-A | Precipitating from a starting material which is a solution of the starting material in an inorganic or organic acid, and precipitating with a base, or a solution of starting material in a chlorinated hydrocarbon, precipitating with hydrocarbon | ARZNEIMITTELWERK DRESDEN GMBH (DD) | 1994-01-25 | — | — | US | disclosed |
| US-5281705-A | Precipitating from a starting material which is a solution of the starting material in an inorganic or organic acid, and precipitating with a base, or a solution of starting material in a chlorinated hydrocarbon, precipitating with hydrocarbon | ARZNEIMITTELWERK DRESDEN GMBH (DD) | 1994-01-25 | — | — | US | disclosed |
| US-5281705-A | Precipitating from a starting material which is a solution of the starting material in an inorganic or organic acid, and precipitating with a base, or a solution of starting material in a chlorinated hydrocarbon, precipitating with hydrocarbon | ARZNEIMITTELWERK DRESDEN GMBH (DD) | 1994-01-25 | — | — | US | disclosed |
| US-5204464-A | Cardiotonic agents, vasodilators | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1993-04-20 | — | — | US | disclosed |
| US-5204464-A | Cardiotonic agents, vasodilators | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1993-04-20 | — | — | US | disclosed |
| US-5162533-A | 3-CYANO-5,4'-BIPYRIDINE-1'-OXIDE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS CONTAINING THE SAME | ARZNEIMITTELWERK DRESDEN G.M.B.H. (DE) | 1992-11-10 | — | — | US | disclosed |
| EP-0200024-B1 | 3-CYANO-PYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1992-07-01 | — | — | EP | disclosed |
| EP-0445553-A1 | Compact crystalline 3-cyano-2-morpholino-5-(pyridyl-4)-pyridine with high bulk density and process for preparation | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1991-09-11 | — | — | EP | disclosed |
| EP-0445553-A1 | Compact crystalline 3-cyano-2-morpholino-5-(pyridyl-4)-pyridine with high bulk density and process for preparation | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1991-09-11 | — | — | EP | disclosed |
| EP-0445553-A1 | Compact crystalline 3-cyano-2-morpholino-5-(pyridyl-4)-pyridine with high bulk density and process for preparation | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1991-09-11 | — | — | EP | disclosed |
| EP-0445552-A1 | 3-Cyano-5,4'-bipyridine-1'-oxides, process for preparation and their pharmaceutical use | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1991-09-11 | — | — | EP | disclosed |
| EP-0200024-A2 | 3-Cyano-pyridines, process for their preparation and their pharmaceutical use | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1986-11-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009970-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES | HTR1A, HTR3B, HTR3A | KDM4E 192/4885RXFP1 2808/4885ALDH1A1 2240/4885 |
| US-20080161324-A1 | Compositions and methods for treatment of viral diseases | HAVCR2, EIF2AK2, RNASE1 | KDM4E 861/4885RXFP1 4270/4885ALDH1A1 785/4885 |
| US-20100092479-A1 | Compositions and methods for treatment of viral diseases | HAVCR2, RNASE1, EIF2AK2 | KDM4E 731/4885RXFP1 4072/4885ALDH1A1 1588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.