Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3363120 | 0.84 | KDM4E (0.42) | ALDH1A1MAPTHPGDSMN1; SMN2LMNA | |
| SCHEMBL3366444 | 0.80 | ESR2 (0.33) | ALDH1A1HPGDSMN1; SMN2HTTPPARG | |
| SCHEMBL14260588 | 0.75 | CSNK2A1 (0.45) | ALDH1A1MAPTHPGDSMN1; SMN2LMNA | |
| SCHEMBL5883139 | 0.73 | ALDH1A1 (0.42) | ALDH1A1MAPTHPGDSMN1; SMN2LMNA | |
| SCHEMBL3363545 | 0.71 | HTR2A (0.36) | — | |
| SCHEMBL3363345 | 0.71 | ALDH1A1 (0.37) | ALDH1A1MAPTHPGDSMN1; SMN2LMNA | |
| SCHEMBL5883581 | 0.71 | ADRB2 (0.48) | ALDH1A1MAPTHPGDSMN1; SMN2LMNA | |
| SCHEMBL5882789 | 0.71 | PTGDR2 (0.36) | ALDH1A1MAPTHPGDSMN1; SMN2LMNA | |
| SCHEMBL5882785 | 0.71 | PTGDR2 (0.36) | ALDH1A1MAPTHPGDSMN1; SMN2LMNA | |
| SCHEMBL9681414 | 0.69 | ALDH1A1 (0.52) | ALDH1A1MAPTHPGDSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996590-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-10-06 | — | — | EP | disclosed |