Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3363120 | 0.81 | KDM4E (0.42) | ALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL3364136 | 0.80 | ALDH1A1 (0.33) | PPARGPPARAALDH1A1HPGDHTT | |
| SCHEMBL16055023 | 0.75 | LMNA (0.45) | ESR2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3362465 | 0.73 | ESR2 (0.35) | ESR2SSTR4PPARGPPARAALDH1A1 | |
| SCHEMBL11111324 | 0.70 | CYP2C9 (0.45) | ESR2ALDH1A1HPGDHTT | |
| SCHEMBL11111329 | 0.70 | CYP2C9 (0.45) | ESR2ALDH1A1HPGDHTT | |
| SCHEMBL3363545 | 0.69 | HTR2A (0.36) | — | |
| SCHEMBL14469045 | 0.69 | CYP2C9 (0.41) | ESR2PPARGPPARAALDH1A1HTT | |
| SCHEMBL25989553 | 0.66 | PTGES (0.37) | ESR2PPARGALDH1A1HPGD | |
| SCHEMBL22040028 | 0.65 | CYP2C9 (0.40) | ESR2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996590-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-10-06 | — | — | EP | disclosed |