Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tetraxetan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.53 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.53 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL308073 | 1.00 | HSD17B10 (0.54) | HSD17B10SLC6A9GLRA1OR51E2KDM4E | |
| Tetraxetan SCHEMBL1496261 | 0.90 | HSD17B10 (0.50) | HSD17B10SLC6A9GLRA1OR51E2KDM4E | |
| SCHEMBL321989 | 0.89 | HSD17B10 (0.64) | HSD17B10SLC6A9KDM4ES1PR1ALDH1A1 | |
| Tetraxetan SCHEMBL2635294 | 0.89 | HSD17B10 (0.64) | HSD17B10SLC6A9KDM4ES1PR1ALDH1A1 | |
| SCHEMBL3660521 | 0.89 | — | — | |
| SCHEMBL173508 | 0.89 | HSD17B10 (0.64) | HSD17B10SLC6A9KDM4ES1PR1ALDH1A1 | |
| Tetraxetan SCHEMBL18018 | 0.89 | HSD17B10 (0.64) | HSD17B10SLC6A9KDM4ES1PR1ALDH1A1 | |
| Tetraxetan SCHEMBL2017956 | 0.89 | HSD17B10 (0.64) | HSD17B10SLC6A9KDM4ES1PR1ALDH1A1 | |
| SCHEMBL6848102 | 0.89 | HSD17B10 (0.64) | HSD17B10SLC6A9KDM4ES1PR1ALDH1A1 | |
| SCHEMBL6744121 | 0.89 | HSD17B10 (0.64) | HSD17B10SLC6A9KDM4ES1PR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020053255-A1 | THERAPEUTIC AND DIAGNOSTIC AGENTS FOR CANCER | Technische Universität München (DE) | 2020-03-19 | — | — | WO | disclosed |
| US-20100311669-A1 | COMPOUNDS THAT BIND TO P185 AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-12-09 | — | — | US | disclosed |
| US-7745577-B2 | Compounds that bind to P185 and methods of using the same | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-06-29 | — | — | US | disclosed |
| US-20070207086-A1 | Compounds that bind to P185 and methods of using the same | UNIVERSITY OF PENNSYLVANIA (US) | 2007-09-06 | — | — | US | disclosed |
| US-7179785-B2 | Compounds that bind to p185 and methods of using the same | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-02-20 | — | — | US | disclosed |
| US-20030148932-A1 | Compounds that bind to p185 and methods of using the same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-08-07 | — | — | US | disclosed |
| WO-2003045309-A2 | Peptides, peptide compositions,and methods of use in binding p 185 | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2003-06-05 | — | — | WO | disclosed |