SCHEMBL3364629

SCHEMBL3364629

O=CC(Br)(Br)c1ccc(F)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 7/20 0.43
RAB9A P51151 2/20 0.37
USP2 O75604 1/20 0.37
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
MAPT P10636 1/20 0.35
XBP1 P17861 1/20 0.35
MAPK1 P28482 1/20 0.35
HTT P42858 1/20 0.35
KMT2A Q03164 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CYP1A1 P04798 1/20 0.35
CYP1B1 Q16678 1/20 0.35
CES2 O00748 1/20 0.35
CES1 P23141 1/20 0.35
CYP19A1 P11511 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7070033 0.79 CES2 (0.46) CES2CES1PTPN1ALDH1A1
SCHEMBL3365770 0.76 CYP2A6 (0.44) MAPK1CES2CES1CA1CA2
SCHEMBL3362928 0.75 KCNN4 (0.48) KCNN4RAB9ACYP3A4CYP2D6NPC1
SCHEMBL3366400 0.74 TSHR (0.48) RAB9ACYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL3424511 0.74 HSD17B10 (0.46) CYP3A4MEN1MAPK1KMT2ACES2
SCHEMBL2397571 0.74 KCNN4 (0.43) KCNN4RAB9AUSP2CYP3A4CYP2D6
SCHEMBL186764 0.72 RAB9A (0.42) KCNN4RAB9AUSP2CYP3A4CYP2D6
SCHEMBL3825948 0.72 KCNN4 (0.46) KCNN4RAB9AUSP2CYP3A4CYP2D6
SCHEMBL4015306 0.72 KCNN4 (0.50) KCNN4RAB9AMEN1NPC1HTT
SCHEMBL4800691 0.71 KCNN4 (0.44) KCNN4RAB9AUSP2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed