Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723483 | 0.93 | GAA (0.40) | TSHRHTTGAAROCK2DPP4 | |
| SCHEMBL7716634 | 0.91 | ABCC1 (0.38) | TSHRHTTGAAROCK2PTPN1 | |
| SCHEMBL3362425 | 0.85 | DPP4 (0.50) | TSHRHTTGAATRPV1ROCK2 | |
| SCHEMBL3362011 | 0.85 | DPP4 (0.40) | TSHRDPP4NPSR1CTSLKMT2A | |
| SCHEMBL3361514 | 0.84 | GAA (0.44) | TSHRHTTGAATRPV1ROCK2 | |
| SCHEMBL3361319 | 0.83 | GAA (0.44) | HTTGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL3361777 | 0.82 | TP53 (0.41) | TSHRROCK2DPP4ROCK1MEN1 | |
| SCHEMBL3365615 | 0.81 | DPP4 (0.41) | HTTGAAROCK2PTPN1DPP4 | |
| SCHEMBL3360962 | 0.79 | DPP4 (0.41) | GAADPP4KMT2A | |
| SCHEMBL3361886 | 0.78 | DPP4 (0.41) | TSHRHTTDPP4ALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732446-B1 | Dipeptidyl peptidase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-08 | — | — | US | disclosed |
| US-7732446-B1 | Dipeptidyl peptidase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-08 | — | — | US | disclosed |