SCHEMBL3367394

SCHEMBL3367394

Cc1ccc(S(=O)(=O)N2CCCC2c2nnc(-c3cccnc3)o2)cc1O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.49
MAPK1 P28482 1/20 0.47
ALDH1A1 P00352 5/20 0.44
MAPT P10636 5/20 0.42
CA2 P00918 1/20 0.42
POLB P06746 2/20 0.42
USP2 O75604 1/20 0.41
ADRB2 P07550 1/20 0.41
TSHR P16473 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C19 P33261 1/20 0.41
TP53 P04637 1/20 0.41
LMNA P02545 2/20 0.40
KDM4E B2RXH2 1/20 0.40
HPGD P15428 1/20 0.40
KMT2A Q03164 1/20 0.40
HSD17B10 Q99714 1/20 0.40
HCRTR1 O43613 2/20 0.40
HCRTR2 O43614 2/20 0.40
GHSR Q92847 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3370579 0.90 MAPT (0.48) NPSR1ALDH1A1MAPTCA2POLB
SCHEMBL3367393 0.87 MAPT (0.51) NPSR1MAPK1ALDH1A1MAPTCA2
SCHEMBL3367330 0.81 SMN1; SMN2 (0.49) ALDH1A1MAPTCA2USP2TSHR
SCHEMBL6178012 0.81 CYP3A4 (0.62) MAPK1ALDH1A1MAPTPOLBUSP2
SCHEMBL3370573 0.76 MAPT (0.55) NPSR1MAPTPOLBTP53LMNA
SCHEMBL3364395 0.74 ALDH1A1 (0.49) NPSR1MAPK1ALDH1A1CYP3A4CYP2C19
SCHEMBL6068971 0.73 HTT (0.51) MAPK1ALDH1A1MAPTPOLBUSP2
SCHEMBL6178979 0.72 PSEN1 (0.57) NPSR1ALDH1A1POLBUSP2ADRB2
SCHEMBL3369442 0.72 ALDH1A1 (0.44) NPSR1MAPK1ALDH1A1MAPTPOLB
SCHEMBL6069077 0.72 ALDH1A1 (0.44) NPSR1MAPK1ALDH1A1HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1532141-B1 2-PYRROLIDIN-2-YL- [1,3,4]-OXADIAZOLE DERIVATIVES AND THE USE OF THE SAME AS ANTIDEPRESSANTS GRUENENTHAL GMBH (DE) 2010-10-13 EP disclosed