Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3369449 | 0.88 | ALDH1A1 (0.46) | ALDH1A1DPP4USP30MAPK1NPSR1 | |
| SCHEMBL3364395 | 0.87 | ALDH1A1 (0.49) | ALDH1A1FKBP1ATNKSPARP1PARP2 | |
| SCHEMBL3364389 | 0.82 | ALDH1A1 (0.44) | ALDH1A1TNKSPARP1PARP2DPP4 | |
| SCHEMBL3366667 | 0.79 | KDM4E (0.43) | ALDH1A1HCRTR1HCRTR2MAPK1NPSR1 | |
| SCHEMBL3369442 | 0.79 | ALDH1A1 (0.44) | ALDH1A1HCRTR1HCRTR2FKBP1AUSP30 | |
| SCHEMBL3366706 | 0.77 | ALDH1A1 (0.42) | ALDH1A1FKBP1AMAPK1NPSR1HTT | |
| SCHEMBL3368142 | 0.77 | CYP2C19 (0.44) | ALDH1A1HCRTR1HCRTR2FKBP1ADPP4 | |
| SCHEMBL3368236 | 0.76 | ALDH1A1 (0.56) | ALDH1A1HCRTR1HCRTR2TNKSPARP1 | |
| SCHEMBL3367393 | 0.74 | MAPT (0.51) | ALDH1A1HCRTR1HCRTR2MAPK1NPSR1 | |
| SCHEMBL3368239 | 0.73 | ALDH1A1 (0.56) | ALDH1A1HCRTR1HCRTR2TNKSPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105538-B2 | 2-pyrrolidin-2-yl-[1,3,4]-oxadiazole compounds and their use as anti-depressants | GRUENENTHAL GMBH (DE) | 2006-09-12 | — | — | US | disclosed |
| US-20050187260-A1 | 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazole compounds and their use as anti-depressants | GRUENENTHAL GMBH (DE) | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187260-A1 | 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazole compounds and their use as anti-depressants | OPRD1, OPRK1, GRIN2C | ALDH1A1 510/4885HCRTR1 461/4885HCRTR2 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.