Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3367326 | 0.87 | KDM4E (0.53) | SMN1; SMN2KDM4EMEN1KMT2AHTT | |
| SCHEMBL3370579 | 0.85 | MAPT (0.48) | SMN1; SMN2KDM4EHTTTP53MAPT | |
| SCHEMBL3367394 | 0.81 | NPSR1 (0.49) | KDM4EKMT2ATP53USP2TSHR | |
| SCHEMBL6180512 | 0.80 | LMNA (0.65) | KDM4EMEN1KMT2AUSP2LMNA | |
| SCHEMBL3366618 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4EMEN1KMT2AHTT | |
| SCHEMBL6178979 | 0.73 | PSEN1 (0.57) | USP2TSHRLMNAALDH1A1GAA | |
| SCHEMBL6180434 | 0.72 | TRPA1 (0.47) | LMNAGAAHSD17B10 | |
| SCHEMBL6179184 | 0.71 | TRPA1 (0.57) | KDM4ELMNAL3MBTL1MAPTHPGD | |
| SCHEMBL3370573 | 0.71 | MAPT (0.55) | SMN1; SMN2TP53TDP1LMNANPC1 | |
| SCHEMBL6180591 | 0.70 | TRPA1 (0.48) | KDM4ETP53USP2TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532141-B1 | 2-PYRROLIDIN-2-YL- [1,3,4]-OXADIAZOLE DERIVATIVES AND THE USE OF THE SAME AS ANTIDEPRESSANTS | GRUENENTHAL GMBH (DE) | 2010-10-13 | — | — | EP | disclosed |