Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 11/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3364228 | 0.88 | CRHR1 (0.46) | CRHR1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL3363623 | 0.87 | CRHR1 (0.42) | CRHR1CNR1DPP4DPP8 | |
| SCHEMBL3367997 | 0.85 | CRHR1 (0.44) | CRHR1KDM4EALDH1A1GAANPC1 | |
| SCHEMBL3368609 | 0.83 | KDM4E (0.45) | CRHR1KDM4ELMNASMN1; SMN2CNR1 | |
| SCHEMBL3366121 | 0.81 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL3364408 | 0.81 | CRHR1 (0.46) | CRHR1ALDH1A1HPGDLMNARAB9A | |
| SCHEMBL3362477 | 0.80 | CRHR1 (0.47) | CRHR1KDM4E | |
| SCHEMBL3366050 | 0.79 | CRHR1 (0.46) | CRHR1CHRM3KDM4EALDH1A1HPGD | |
| SCHEMBL3367673 | 0.79 | S1PR4 (0.38) | CRHR1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL3364735 | 0.79 | CRHR1 (0.51) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656353-B1 | GABANERGIC MODULATORS | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | claimed |