Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399462 | 0.81 | KMT2A (0.45) | HDAC1HDAC8SMN1; SMN2EGFRERBB2 | |
| SCHEMBL3367784 | 0.78 | SMN1; SMN2 (0.37) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL5643243 | 0.76 | ALDH1A1 (0.43) | SMN1; SMN2KMT2AAKR1C3AKR1C2LMNA | |
| SCHEMBL3366546 | 0.70 | TP53 (0.49) | SMN1; SMN2KMT2A | |
| SCHEMBL1860344 | 0.69 | KMT2A (0.49) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL21647723 | 0.68 | SMN1; SMN2 (0.46) | SMN1; SMN2EGFRERBB2KMT2ABRD4 | |
| SCHEMBL21647692 | 0.66 | SMN1; SMN2 (0.60) | SMN1; SMN2KMT2ALMNAHTTMTNR1A | |
| SCHEMBL3367782 | 0.65 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAHTT | |
| SCHEMBL23706376 | 0.63 | SMN1; SMN2 (0.41) | SMN1; SMN2EGFRERBB2MAOBMAOA | |
| SCHEMBL7988653 | 0.62 | MAOB (0.41) | HDAC1HDAC8HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335901-B1 | PHARMACEUTICALLY ACTIVE SULFANILIDE DERIVATIVES | MERCK SERONO SA (CH) | 2010-04-14 | — | — | EP | disclosed |
| US-7312358-B2 | Pharmaceutically active sulfanilide derivatives | LABORATOIRES SERONO SA (CH) | 2007-12-25 | — | — | US | disclosed |