Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8004385 | 0.92 | HSD17B3 (0.46) | MAOBMAOAALDH1A1MAPTHSD17B3 | |
| SCHEMBL8002639 | 0.86 | NFE2L2 (0.43) | MAOBMAOAMAPTNFE2L2HSD17B3 | |
| SCHEMBL8001632 | 0.82 | MAPT (0.48) | MAOBMAOAMAPTPPARGLMNA | |
| SCHEMBL8002658 | 0.80 | NFE2L2 (0.45) | NFE2L2 | |
| SCHEMBL7998811 | 0.80 | LMNA (0.43) | ALDH1A1MAPTLMNANFE2L2HSD17B3 | |
| SCHEMBL8002290 | 0.78 | MAOB (0.47) | MAOBMAPTNFE2L2KMT2A | |
| SCHEMBL8001633 | 0.78 | NFE2L2 (0.50) | MAOBALDH1A1MAPTPPARGLMNA | |
| SCHEMBL7988652 | 0.77 | PPARG (0.44) | MAOBMAPTPPARGLMNAKMT2A | |
| SCHEMBL8002292 | 0.75 | LMNA (0.40) | MAPTLMNANFE2L2HSD17B3 | |
| SCHEMBL7998748 | 0.75 | CYP19A1 (0.41) | MAOBMAOAALDH1A1MAPTPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009120783-A1 | HIGH AFFINITY INHIBITORS OF HEPATITIS C VIRUS NS3/4A PROTEASE | THE JOHNS HOPKINS UNIVERSITY (US) | 2009-10-01 | — | — | WO | disclosed |