Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 9/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 2/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13531352 | 0.90 | TRPA1 (0.43) | EGFRHTR2ASLC6A4KCNH2KDR | |
| SCHEMBL3366738 | 0.88 | EGFR (0.46) | EGFRHTR2ASLC6A4KCNH2KDR | |
| SCHEMBL248689 | 0.81 | TRPA1 (0.45) | EGFRHTR2ASLC6A4KCNH2KDR | |
| SCHEMBL6938479 | 0.76 | KDR (0.48) | HTR2ASLC6A4KCNH2KDRKMO | |
| SCHEMBL7781852 | 0.76 | KDR (0.48) | HTR2ASLC6A4KCNH2KDRAR | |
| SCHEMBL8773800 | 0.76 | KDR (0.48) | HTR2ASLC6A4KCNH2KDRAR | |
| SCHEMBL679527 | 0.75 | KDR (0.49) | HTR2ASLC6A4KCNH2KDRKMO | |
| SCHEMBL3929860 | 0.73 | CDK8 (0.41) | HTR2ASLC6A4KCNH2KDRTRPA1 | |
| SCHEMBL7885594 | 0.72 | KDR (0.46) | HTR2ASLC6A4KCNH2KDRKMO | |
| SCHEMBL1456728 | 0.72 | TRPA1 (0.45) | EGFRTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268446-B1 | METHOD FOR PRODUCING ASYMMETRICAL 4,6-BIS(ARYLOXY)PYRIMIDINE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2010-10-06 | — | — | EP | disclosed |
| EP-1268446-B1 | METHOD FOR PRODUCING ASYMMETRICAL 4,6-BIS(ARYLOXY)PYRIMIDINE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2010-10-06 | — | — | EP | disclosed |
| US-6734304-B2 | REACTING THE CORRESPONDING 4.6-DIHALOPYRIMIDINE COMPOUND WITH BASE; ONE POT PROCESS | BAYER AKTIENGESELLSCHAFT (DE) | 2004-05-11 | — | — | US | disclosed |
| US-20030092723-A1 | Method for producing asymmetrical 4,6-bis(aryloxy)pyrimidine derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2003-05-15 | — | — | US | disclosed |
| EP-1268446-A1 | METHOD FOR PRODUCING ASYMMETRICAL 4,6-BIS(ARYLOXY)PYRIMIDINE DERIVATIVES | Bayer CropScience AG (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072719-A1 | METHOD FOR PRODUCING ASYMMETRICAL 4,6-BIS(ARYLOXY)PYRIMIDINE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092723-A1 | Method for producing asymmetrical 4,6-bis(aryloxy)pyrimidine derivatives | DPYD, TYMS, TYMP | EGFR 1743/4885HTR2A 1176/4885SLC6A4 1294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.