Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | KMO | O15229 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.39 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8773800 | 1.00 | KDR (0.48) | KDRFLT1FLT4MAP2K7KCNH2 | |
| SCHEMBL8773810 | 0.92 | KDR (0.46) | KDRFLT1FLT4MAP2K7KCNH2 | |
| SCHEMBL6938479 | 0.90 | KDR (0.48) | KDRFLT1FLT4MAP2K7KCNH2 | |
| SCHEMBL679527 | 0.87 | KDR (0.49) | KDRFLT1FLT4MAP2K7KCNH2 | |
| SCHEMBL7791086 | 0.87 | KDR (0.49) | KDRBRAFKMORAF1MAPK3 | |
| SCHEMBL7885594 | 0.85 | KDR (0.46) | KDRFLT1FLT4MAP2K7KCNH2 | |
| SCHEMBL8439101 | 0.83 | KDR (0.44) | KDRFLT1FLT4MAP2K7KCNH2 | |
| SCHEMBL7545999 | 0.83 | TRPV1 (0.50) | KDRFLT1FLT4MAP2K7KCNH2 | |
| SCHEMBL8773801 | 0.81 | KDR (0.47) | KDRFLT1FLT4MAP2K7BRAF | |
| SCHEMBL8683754 | 0.80 | ALDH1A1 (0.47) | KDRFLT1FLT4MAP2K7BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902020-B1 | Improved process for the preparation of unsymmetrical 4,6-bis (aryloxy) pyrimidine compounds | BASF AG (DE) | 2001-11-28 | — | — | EP | disclosed |
| EP-0794177-B1 | Process for the preparation of unsymmertical 4,6-Bis (aryloxy pyrimidine compounds | AMERICAN CYANAMID CO (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6087498-A | Process for the preparation of unsymmetrical 4,6-bis(aryloxy) pyrimidine compounds | AMERICAN CYANAMID COMPANY (US) | 2000-07-11 | — | — | US | disclosed |
| US-5977363-A | Process for the preparation of unsymmetrical 4,6-bis(aryloxy) pyrimidine compounds | AMERICAN CYANAMID COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0902020-A1 | Improved process for the preparation of unsymmetrical 4,6-bis (aryloxy) pyrimidine compounds | American Cyanamid Company (US) | 1999-03-17 | — | — | EP | disclosed |
| US-5849910-A | Process for the preparation of unsymmetrical 4,6-bis aryloxy-pyrimidine compounds | AMERICAN CYANAMID COMPANY (US) | 1998-12-15 | — | — | US | disclosed |
| EP-0794177-A1 | Process for the preparation of unsymmertical 4,6-Bis (aryloxy pyrimidine compounds | American Cyanamid Company (US) | 1997-09-10 | — | — | EP | disclosed |