Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185593 | 0.78 | PTGS2 (0.35) | KDM4EL3MBTL1ALDH1A1BRD4EGFR | |
| SCHEMBL10816405 | 0.73 | PSIP1 (0.39) | KDM4ECYP3A4CYP2C9ALDH1A1MAPT | |
| SCHEMBL475089 | 0.71 | ALDH1A1 (0.55) | KDM4EPOLBCYP3A4CYP2C9L3MBTL1 | |
| SCHEMBL29468592 | 0.71 | ALDH1A1 (0.55) | KDM4EPOLBCYP3A4CYP2C9L3MBTL1 | |
| SCHEMBL3371382 | 0.68 | KDM4E (0.41) | KDM4EPOLBCYP3A4CYP2C9L3MBTL1 | |
| SCHEMBL29547 | 0.66 | AHR (0.37) | KDM4ECYP3A4ALDH1A1MAPTHTT | |
| SCHEMBL6668140 | 0.65 | NPC1 (0.42) | CYP3A4ALDH1A1MAPTHTTBRD4 | |
| SCHEMBL31092469 | 0.64 | HTR6 (0.57) | KDM4EPOLBCYP3A4CYP2C9L3MBTL1 | |
| SCHEMBL1713160 | 0.64 | HTR6 (0.57) | KDM4EPOLBCYP3A4CYP2C9L3MBTL1 | |
| SCHEMBL27623150 | 0.64 | ALDH1A1 (0.49) | KDM4EPOLBCYP3A4CYP2C9L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641792-B1 | PYRROLODIHYDROISOQUINOLINES AS PDE10 INHIBITORS | NYCOMED GMBH (DE) | 2010-08-25 | — | — | EP | claimed |
| US-20060148840-A1 | Pyrrolodihydroisoquinolines as pde10 inhibitors | ALTANA PHARMA AG (DE) | 2006-07-06 | — | — | US | claimed |
| EP-1641792-A1 | PYRROLODIHYDROISOQUINOLINES AS PDE10 INHIBITORS | ALTANA Pharma AG (DE) | 2006-04-05 | — | — | EP | claimed |
| WO-2005003129-A1 | PYRROLODIHYDROISOQUINOLINES AS PDE10 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-01-13 | — | — | WO | claimed |
| EP-1641792-B1 | PYRROLODIHYDROISOQUINOLINES AS PDE10 INHIBITORS | NYCOMED GMBH (DE) | 2010-08-25 | — | — | EP | disclosed |
| EP-1641457-B1 | PYRROLO-DIHYDROISOQUINOLINE DERIVATIVES AS PDE10 INHIBITORS | NYCOMED GMBH (DE) | 2009-08-05 | — | — | EP | disclosed |
| EP-1838707-B1 | NOVEL PYRROLODIHYDROISOQUINOLINES AS PDE10 INHIBITORS | NYCOMED GMBH (DE) | 2009-04-29 | — | — | EP | disclosed |
| US-20080161338-A1 | Novel Pyrrolodihydroisoquinolines as Pde 10 Inhibitors | ALTANA PHARMA AG (DE) | 2008-07-03 | — | — | US | disclosed |
| US-20070105840-A1 | Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors | ALTANA PHARMA AG (DE) | 2007-05-10 | — | — | US | disclosed |
| US-20060148840-A1 | Pyrrolodihydroisoquinolines as pde10 inhibitors | ALTANA PHARMA AG (DE) | 2006-07-06 | — | — | US | disclosed |
| EP-1641792-A1 | PYRROLODIHYDROISOQUINOLINES AS PDE10 INHIBITORS | ALTANA Pharma AG (DE) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005003129-A1 | PYRROLODIHYDROISOQUINOLINES AS PDE10 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148840-A1 | Pyrrolodihydroisoquinolines as pde10 inhibitors | PDE12, PDE3A, PDE3B | KDM4E 269/4885POLB 1637/4885CYP3A4 1333/4885 |
| US-20080161338-A1 | Novel Pyrrolodihydroisoquinolines as Pde 10 Inhibitors | PDE12, PDE5A, PDE3A | KDM4E 202/4885POLB 1782/4885CYP3A4 1160/4885 |
| US-20070105840-A1 | Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors | PDE12, PDE2A, PDE5A | KDM4E 847/4885POLB 481/4885CYP3A4 2025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.