Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9506721 | 0.74 | KMT2A (0.42) | ALDH1A1KMT2ABACE1MAPK1PDE4B | |
| SCHEMBL14663755 | 0.74 | KMT2A (0.42) | ALDH1A1KMT2ABACE1MAPK1PDE4B | |
| SCHEMBL6151731 | 0.72 | ALDH1A1 (0.33) | ALDH1A1KMT2ABACE1MAPK1PDE4B | |
| Hydrochloric Acid SCHEMBL3372048 | 0.71 | ALDH1A1 (0.32) | ALDH1A1KMT2ABACE1MAPK1PDE4B | |
| SCHEMBL19469401 | 0.67 | KDM4E (0.42) | ALDH1A1MAPK1POLB | |
| SCHEMBL8191410 | 0.64 | BACE1 (0.44) | ALDH1A1KMT2ABACE1MAPK1 | |
| Hydrochloric Acid SCHEMBL3373258 | 0.64 | CFTR (0.41) | ALDH1A1KMT2ANOTUM | |
| SCHEMBL29035103 | 0.64 | BACE1 (0.45) | ALDH1A1KMT2ABACE1PDE4B | |
| SCHEMBL532970 | 0.61 | ALDH1A1 (0.67) | ALDH1A1KMT2ABACE1MAPK1NOTUM | |
| SCHEMBL532969 | 0.61 | ALDH1A1 (0.67) | ALDH1A1KMT2ABACE1MAPK1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010055935-A1 | ETHYLENE-α-OLEFIN COPOLYMER AND MOLDED OBJECT THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-05-20 | — | — | WO | disclosed |
| US-6124489-A | Preparation of bis aryl cyclopentadienyl Group IVA metal dihalides | BOULDER SCIENTIFIC COMPANY (US) | 2000-09-26 | — | — | US | disclosed |