Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL147807 | 0.81 | CFTR (0.52) | CFTRGOPCKMT2APTGS2PTGS1 | |
| SCHEMBL8197843 | 0.81 | CFTR (0.52) | CFTRGOPCKMT2APTGS2PTGS1 | |
| Hydrochloric Acid SCHEMBL7758771 | 0.76 | CFTR (0.43) | CFTRGOPCKMT2APTGS2PTGS1 | |
| Hydrochloric Acid SCHEMBL9066149 | 0.72 | CFTR (0.40) | CFTRGOPCKMT2APTGS2PTGS1 | |
| Hydrochloric Acid SCHEMBL3373261 | 0.70 | CFTR (0.46) | CFTRGOPCKMT2APTGS2PTGS1 | |
| Hydrochloric Acid SCHEMBL7760049 | 0.70 | CFTR (0.41) | CFTRGOPCKMT2APTGS2PTGS1 | |
| SCHEMBL1044880 | 0.70 | ESR1 (0.42) | CFTRGOPCKMT2APTGS2PTGS1 | |
| Hydrochloric Acid SCHEMBL9066523 | 0.68 | CFTR (0.40) | CFTRGOPCKMT2APTGS2PTGS1 | |
| SCHEMBL868869 | 0.67 | CFTR (0.68) | CFTRGOPCKMT2APTGS2PTGS1 | |
| SCHEMBL6151994 | 0.67 | CFTR (0.43) | CFTRGOPCKMT2APTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102209734-A | Ethylene-alpha-olefin copolymer and formed body | SUMITOMO CHEMICAL CO | 2011-10-05 | — | — | CN | disclosed |
| WO-2010055935-A1 | ETHYLENE-α-OLEFIN COPOLYMER AND MOLDED OBJECT THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-05-20 | — | — | WO | disclosed |