Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8251126 | 0.92 | MAPK14 (0.55) | SRD5A1MAPK14PARP1PARP10 | |
| SCHEMBL6954820 | 0.90 | MAPK14 (0.65) | SRD5A1MAPK14 | |
| SCHEMBL29726050 | 0.84 | CASP1 (0.59) | SRD5A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL192610 | 0.84 | CASP1 (0.59) | SRD5A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL11685606 | 0.84 | MAPK14 (0.60) | SRD5A1MAPK14 | |
| SCHEMBL5518824 | 0.82 | PARP1 (0.58) | SRD5A1MAPK14PARP1PARP10 | |
| SCHEMBL4041628 | 0.80 | MAPK14 (0.70) | SRD5A1MAPK14CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL1512613 | 0.78 | BCHE (0.52) | SRD5A1MAPK14PARP1PARP10 | |
| SCHEMBL4157894 | 0.78 | TDP1 (0.64) | SRD5A1MAPK14PARP1PARP10 | |
| SCHEMBL9829298 | 0.78 | MAPK14 (0.55) | SRD5A1MAPK14CYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260062397-A1 | 2-DIARYLMETHYL-4-AMINOTETRAHYDROPYRAN DERIVATIVES AND RELATED COMPOUNDS AS ANTICANCER, ANTIINFLAMMATORY, ANTIFIBROTIC AND NEUROPROTECTIVE AGENTS | ATUX ISKAY LLC (US) | 2026-03-05 | — | — | US | disclosed |
| US-12522575-B2 | 2-diarylmethyl-4-aminotetrahydropyran derivatives and related compounds as anticancer, antiinflammatory, antifibrotic and neuroprotective agents | ATUX ISKAY LLC (US) | 2026-01-13 | — | — | US | disclosed |
| US-20250376455-A1 | 2-DIARYLMETHYL-4-AMINOTETRAHYDROPYRAN DERIVATIVES AND RELATED COMPOUNDS AS ANTICANCER, ANTIINFLAMMATORY, ANTIFIBROTIC AND NEUROPROTECTIVE AGENTS | ATUX ISKAY LLC (US) | 2025-12-11 | — | — | US | disclosed |
| US-20250340514-A1 | 3-DIARYLMETHYLENES AND USES THEREOF | ATUX ISKAY LLC (US) | 2025-11-06 | — | — | US | disclosed |
| US-12398103-B2 | 3-diarylmethylenes and uses thereof | ATUX ISKAY LLC (US) | 2025-08-26 | — | — | US | disclosed |
| US-20240368105-A1 | 2-DIARYLMETHYL-4-AMINOTETRAHYDROPYRAN DERIVATIVES AND RELATED COMPOUNDS AS ANTICANCER, ANTIINFLAMMATORY, ANTIFIBROTIC AND NEUROPROTECTIVE AGENTS | ATUX ISKAY LLC | 2024-11-07 | — | — | US | disclosed |
| EP-4387962-A1 | 2-DIARYLMETHYL-4-AMINOTETRAHYDROPYRAN DERIVATIVES AND RELATED COMPOUNDS AS ANTICANCER, ANTIINFLAMMATORY, ANTIFIBROTIC AND NEUROPROTECTIVE AGENTS | Atux Iskay LLC (US) | 2024-06-26 | — | — | EP | disclosed |
| WO-2023023594-A9 | 2‑DIARYLMETHYL‑4‑AMINOTETRAHYDROPYRAN DERIVATIVES AND RELATED COMPOUNDS AS ANTICANCER, ANTIINFLAMMATORY, ANTIFIBROTIC AND NEUROPROTECTIVE AGENTS | ATUX ISKAY LLC (US) | 2023-06-08 | — | — | WO | disclosed |
| WO-2023023594-A9 | 2‑DIARYLMETHYL‑4‑AMINOTETRAHYDROPYRAN DERIVATIVES AND RELATED COMPOUNDS AS ANTICANCER, ANTIINFLAMMATORY, ANTIFIBROTIC AND NEUROPROTECTIVE AGENTS | ATUX ISKAY LLC (US) | 2023-06-08 | — | — | WO | disclosed |
| US-20230146127-A1 | 3-DIARYLMETHYLENES AND USES THEREOF | ATUX ISKAY LLC | 2023-05-11 | — | — | US | disclosed |
| EP-3778603-A1 | 7,8-DIHYDRO-3H-PYRAZINO[1,2-B]PYRIDAZINE-3,5(6H)-DIONE COMPOUNDS AND USES THEREOF | Janssen BioPharma, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3030566-B1 | 7,8-DIHYDRO-3H-PYRAZINO[1,2-B]PYRIDAZINE-3,5(6H)-DIONE COMPOUNDS AND USES THEREOF | JANSSEN BIOPHARMA INC (US) | 2020-07-08 | — | — | EP | disclosed |
| US-10702523-B2 | AZA-pyridone compounds and uses thereof | Janssen Biopharma, Inc. (US) | 2020-07-07 | — | — | US | disclosed |
| US-20200030328-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | Janssen Biopharma, Inc. (US) | 2020-01-30 | — | — | US | disclosed |
| US-20190314373-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA, INC. (US) | 2019-10-17 | — | — | US | disclosed |
| US-10251882-B2 | Aza-pyridone compounds and uses thereof | ALIOS BIOPHARMA, INC. (US) | 2019-04-09 | — | — | US | disclosed |
| US-20160228438-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA, INC. | 2016-08-11 | — | — | US | disclosed |
| EP-1716132-B1 | SPIRO-BENZODIOXOLES AND THEIR USE AS CB1 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-08-25 | — | — | EP | disclosed |
| US-7144890-B2 | Spiro-pentacyclic compounds | HOFFMAN-LA ROCHE INC. (US) | 2006-12-05 | — | — | US | disclosed |
| US-20050165012-A1 | Spiro-pentacyclic compounds | HOFFMANN-LA ROCHE INC. | 2005-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200030328-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | SRD5A1 2062/4885MAPK14 2439/4885CYP19A1 2620/4885 |
| US-12398103-B2 | 3-diarylmethylenes and uses thereof | MYC, MYCBP, FOXO1 | SRD5A1 2692/4885MAPK14 635/4885CYP19A1 1981/4885 |
| US-20250340514-A1 | 3-DIARYLMETHYLENES AND USES THEREOF | MYC, MYCBP, FOXO1 | SRD5A1 2692/4885MAPK14 635/4885CYP19A1 1981/4885 |
| US-20240368105-A1 | 2-DIARYLMETHYL-4-AMINOTETRAHYDROPYRAN DERIVATIVES AND RELATED COMPOUNDS AS ANTICANCER, ANTIINFLAMMATORY, ANTIFIBROTIC AND NEUROPROTECTIVE AGENTS | MYC, MYCBP, MYCBP2 | SRD5A1 3217/4885MAPK14 322/4885CYP19A1 4030/4885 |
| US-20230146127-A1 | 3-DIARYLMETHYLENES AND USES THEREOF | MYC, MYCBP, FOXO1 | SRD5A1 2692/4885MAPK14 635/4885CYP19A1 1981/4885 |
| US-20190314373-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | SRD5A1 2062/4885MAPK14 2439/4885CYP19A1 2620/4885 |
| US-10251882-B2 | Aza-pyridone compounds and uses thereof | PNPO, ITPA, PDXK | SRD5A1 2062/4885MAPK14 2439/4885CYP19A1 2620/4885 |
| US-10702523-B2 | AZA-pyridone compounds and uses thereof | PNPO, ITPA, PDXK | SRD5A1 2062/4885MAPK14 2439/4885CYP19A1 2620/4885 |
| US-20050165012-A1 | Spiro-pentacyclic compounds | CNR1, CNR2, GPR119 | SRD5A1 285/4885MAPK14 1479/4885CYP19A1 212/4885 |
| US-20250376455-A1 | 2-DIARYLMETHYL-4-AMINOTETRAHYDROPYRAN DERIVATIVES AND RELATED COMPOUNDS AS ANTICANCER, ANTIINFLAMMATORY, ANTIFIBROTIC AND NEUROPROTECTIVE AGENTS | MYC, MYCBP, MYCBP2 | SRD5A1 3217/4885MAPK14 322/4885CYP19A1 4030/4885 |
| US-20160228438-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | SRD5A1 2062/4885MAPK14 2439/4885CYP19A1 2620/4885 |
| US-20260062397-A1 | 2-DIARYLMETHYL-4-AMINOTETRAHYDROPYRAN DERIVATIVES AND RELATED COMPOUNDS AS ANTICANCER, ANTIINFLAMMATORY, ANTIFIBROTIC AND NEUROPROTECTIVE AGENTS | MYC, MYCBP, FOXO1 | SRD5A1 3820/4885MAPK14 504/4885CYP19A1 3692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.