Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3371738 | 0.92 | GPR119 (0.60) | GPR119MAPTTP53MEN1KMT2A | |
| SCHEMBL3373467 | 0.86 | GPR119 (0.50) | GPR119MAPTTP53SMN1; SMN2 | |
| SCHEMBL3374362 | 0.85 | GPR119 (0.52) | GPR119MAPTTP53MEN1KMT2A | |
| SCHEMBL3342654 | 0.79 | GPR119 (0.61) | GPR119 | |
| SCHEMBL3376459 | 0.75 | TP53 (0.48) | GPR119MAPTTP53MEN1KMT2A | |
| SCHEMBL903908 | 0.75 | GPR119 (0.52) | GPR119MAPTTP53MEN1KMT2A | |
| SCHEMBL3342698 | 0.75 | GPR119 (0.68) | GPR119 | |
| SCHEMBL3373764 | 0.74 | CHEK2 (0.52) | GPR119MAPTTP53MEN1KMT2A | |
| SCHEMBL3372018 | 0.74 | GPR119 (0.48) | GPR119MAPTTP53SMN1; SMN2 | |
| SCHEMBL3372327 | 0.74 | GPR119 (0.49) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |