Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3371738 | 0.83 | GPR119 (0.60) | GPR119MAPTTP53MEN1KMT2A | |
| SCHEMBL3373100 | 0.75 | GPR119 (0.52) | GPR119MAPTTP53MEN1KMT2A | |
| SCHEMBL3374362 | 0.75 | GPR119 (0.52) | GPR119MAPTTP53MEN1KMT2A | |
| SCHEMBL904206 | 0.74 | GPR119 (0.52) | GPR119 | |
| SCHEMBL903942 | 0.73 | MAPT (0.44) | GPR119MAPTTP53MEN1KMT2A | |
| SCHEMBL1950704 | 0.72 | GPR119 (0.72) | GPR119MAPTTP53MEN1KMT2A | |
| SCHEMBL10068057 | 0.71 | NPC1 (0.40) | GPR119 | |
| SCHEMBL904207 | 0.71 | GPR119 (0.60) | GPR119MAPTSMN1; SMN2POLBRXFP1 | |
| SCHEMBL3688791 | 0.71 | GPR119 (0.66) | GPR119MAPTTP53MEN1KMT2A | |
| SCHEMBL14314901 | 0.71 | GPR119 (0.65) | GPR119CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |