Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.49 |
| ▸ | DPP4 | P27487 | 2/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3372121 | 0.91 | GPR119 (0.58) | CHEK2GPR119MAPTSMN1; SMN2MEN1 | |
| SCHEMBL3372317 | 0.85 | GPR119 (0.50) | CHEK2GPR119MAPTTP53SMN1; SMN2 | |
| SCHEMBL3370707 | 0.85 | GPR119 (0.50) | CHEK2GPR119SMN1; SMN2PTPN2PTPN1 | |
| SCHEMBL3373458 | 0.78 | GPR119 (0.56) | CHEK2GPR119MAPTTP53SMN1; SMN2 | |
| SCHEMBL24721341 | 0.78 | GPR119 (0.53) | CHEK2GPR119MAPTPTPN2PTPN1 | |
| SCHEMBL3343217 | 0.77 | GPR119 (0.69) | CHEK2GPR119 | |
| SCHEMBL18319425 | 0.77 | GPR119 (0.54) | CHEK2GPR119 | |
| SCHEMBL18318690 | 0.76 | PIK3CD (0.59) | CHEK2GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL904065 | 0.76 | GPR119 (0.52) | CHEK2GPR119MAPTSMN1; SMN2MEN1 | |
| SCHEMBL18318062 | 0.76 | USP30 (0.54) | CHEK2GPR119PTPN2PTPN1PTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |