Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3373277 | 0.86 | GPR119 (0.48) | GPR119CHEK2TP53 | |
| SCHEMBL3373619 | 0.83 | CHEK2 (0.47) | GPR119CHEK2 | |
| SCHEMBL3343172 | 0.82 | GPR119 (0.55) | GPR119 | |
| SCHEMBL3376775 | 0.79 | GPR119 (0.46) | GPR119 | |
| SCHEMBL23410251 | 0.78 | GPR119 (0.67) | GPR119CHEK2 | |
| SCHEMBL2556388 | 0.74 | GPR119 (0.63) | GPR119CHEK2 | |
| SCHEMBL2556386 | 0.74 | GPR119 (0.63) | GPR119CHEK2 | |
| SCHEMBL3344227 | 0.74 | GPR119 (0.53) | GPR119 | |
| SCHEMBL3373283 | 0.73 | GPR119 (0.54) | GPR119 | |
| SCHEMBL21723242 | 0.73 | GPR119 (0.51) | GPR119CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |