Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3374582 | 0.86 | GPR119 (0.45) | GPR119ACACBKCNH2SCN5ASCN9A | |
| SCHEMBL3374664 | 0.85 | GPR119 (0.48) | GPR119ACACB | |
| SCHEMBL3346737 | 0.80 | GPR119 (0.49) | GPR119 | |
| SCHEMBL3373531 | 0.79 | GPR119 (0.45) | GPR119 | |
| SCHEMBL3804747 | 0.72 | GPR119 (0.35) | GPR119 | |
| SCHEMBL3348812 | 0.72 | GPR119 (0.48) | GPR119ACACB | |
| SCHEMBL15253315 | 0.72 | GPR119 (0.58) | GPR119 | |
| SCHEMBL3807071 | 0.71 | GPR119 (0.34) | GPR119 | |
| SCHEMBL3346467 | 0.71 | GPR119 (0.46) | GPR119 | |
| SCHEMBL13423111 | 0.71 | GPR119 (0.57) | GPR119KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |