Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4609709 | 0.86 | LTB4R2 (0.60) | LTB4R2BDKRB1CYP3A4CYP2C19POLB | |
| SCHEMBL10027906 | 0.80 | LTB4R2 (0.58) | LTB4R2CTSBCTSSBDKRB1AGTR1 | |
| SCHEMBL14038695 | 0.80 | LTB4R2 (0.38) | LTB4R2AGTR1AGTR2CYP3A4ABCC3 | |
| SCHEMBL3169268 | 0.79 | CTSB (0.49) | LTB4R2CTSBCTSSBDKRB1AGTR1 | |
| SCHEMBL2959 | 0.79 | AGTR1 (0.47) | LTB4R2AGTR1AGTR2ABCB11 | |
| SCHEMBL3370402 | 0.78 | AGTR1 (0.46) | LTB4R2CTSBCTSSBDKRB1AGTR1 | |
| SCHEMBL9672280 | 0.78 | CTSB (0.51) | LTB4R2CTSBCTSSBDKRB1AGTR1 | |
| SCHEMBL8472336 | 0.77 | AGTR1 (0.37) | LTB4R2AGTR1AGTR2CYP3A4ABCC3 | |
| SCHEMBL5592312 | 0.76 | LTB4R2 (0.45) | LTB4R2AGTR1ABCB11 | |
| SCHEMBL5489422 | 0.76 | LTB4R2 (0.42) | LTB4R2AGTR1AGTR2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113933414-B | Method for detecting organic impurities in amlodipine besylate composite preparation | 株洲千金药业股份有限公司 | 2023-07-07 | — | — | CN | claimed |
| CN-111053910-A | Composition comprising fatty acid or derivative thereof and disubstituted biphenyl derivative | 黄泳华 | 2020-04-24 | — | — | CN | claimed |
| CN-118243800-A | Method for measuring related substances of irbesartan amlodipine tablets | 珠海润都制药股份有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-111053910-A | Composition comprising fatty acid or derivative thereof and disubstituted biphenyl derivative | 黄泳华 | 2020-04-24 | — | — | CN | disclosed |
| EP-2194050-A1 | A new process for the preparation of irbesartan | KRKA, tovarna zdravil, d.d., Novo mesto (SI) | 2010-06-09 | — | — | EP | disclosed |