Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 4/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.44 |
| ▸ | AGT | P01019 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3948155 | 0.87 | LTB4R2 (0.57) | AGTR1AGTR2LTB4R2AGTPOLB | |
| SCHEMBL13679199 | 0.80 | AGTR1 (0.47) | AGTR1AGTR2LTB4R2AGTACHE | |
| SCHEMBL3373560 | 0.78 | LTB4R2 (0.46) | AGTR1AGTR2LTB4R2CTSBCTSS | |
| SCHEMBL4735569 | 0.76 | SOAT1 (0.47) | AGTR1AGTR2POLBHPGD | |
| SCHEMBL10027906 | 0.76 | LTB4R2 (0.58) | AGTR1AGTR2LTB4R2CTSBCTSS | |
| SCHEMBL9541811 | 0.75 | AGTR1 (0.50) | AGTR1AGTR2AGT | |
| SCHEMBL3169268 | 0.75 | CTSB (0.49) | AGTR1AGTR2LTB4R2CTSBCTSS | |
| SCHEMBL9084585 | 0.75 | AGTR1 (0.47) | AGTR1AGTR2LTB4R2AGT | |
| SCHEMBL489527 | 0.75 | AGTR1 (0.49) | AGTR1AGTR2AGTCYP2C19 | |
| SCHEMBL9413763 | 0.74 | AGTR1 (0.45) | AGTR1AGTR2AGT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194050-A1 | A new process for the preparation of irbesartan | KRKA, tovarna zdravil, d.d., Novo mesto (SI) | 2010-06-09 | — | — | EP | disclosed |