Halosulfuron

Halosulfuron

SCHEMBL3374072

COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2c(C(=O)O)c(Cl)nn2C)n1.COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2c(Cl)nc3ccccn23)n1

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.44
MAPT P10636 3/20 0.39
TP53 P04637 1/20 0.39
GLA P06280 1/20 0.39
RAB9A P51151 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
MAPK1 P28482 2/20 0.38
ALDH1A1 P00352 3/20 0.38
CDK1 P06493 1/20 0.37
KMT2A Q03164 1/20 0.35
KDM4E B2RXH2 1/20 0.35
PKM P14618 1/20 0.35
HPGD P15428 1/20 0.35
HSD17B10 Q99714 1/20 0.35
NTRK1 P04629 1/20 0.34
ACLY P53396 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL55236 0.91 GAA (0.52) GAAMAPTTP53GLARAB9A
SCHEMBL8535700 0.91 GAA (0.52) GAAMAPTTP53GLARAB9A
Halosulfuron SCHEMBL66216 0.88 GAA (0.52) GAAMAPTTP53GLASMN1; SMN2
SCHEMBL9362781 0.86 GAA (0.46) GAAMAPTTP53GLARAB9A
SCHEMBL12633039 0.85 GAA (0.46) GAAMAPTTP53GLARAB9A
Halosulfuron SCHEMBL22721319 0.85 GAA (0.48) GAAMAPTTP53GLAALDH1A1
SCHEMBL10673663 0.83 GAA (0.46) GAAMAPTTP53GLASMN1; SMN2
SCHEMBL9517874 0.81 MAPT (0.45) GAAMAPTTP53GLARAB9A
SCHEMBL8480505 0.81 GAA (0.53) GAAMAPTTP53GLAALDH1A1
SCHEMBL55094 0.81 GAA (0.52) GAAMAPTTP53GLAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1916889-A4 METHODS OF ALTERING POPPY CHARACTERISTICS GLAXOSMITHKLINE AUSTRALIA PTY (AU) 2009-03-11 EP claimed
US-20080269058-A1 Methods of Altering Poppy Characteristics SUN PHARMACEUTICAL INDUSTRIES (AUSTRALIA) PTY LTD (AU) 2008-10-30 US claimed
EP-1916889-A1 METHODS OF ALTERING POPPY CHARACTERISTICS Glaxosmithkline Australia PTY Ltd. (AU) 2008-05-07 EP claimed
WO-2007022561-A1 METHODS OF ALTERING POPPY CHARACTERISTICS GLAXOSMITHKLINE AUSTRALIA PTY LTD (AU) 2007-03-01 WO claimed
US-8557737-B2 Methods of altering poppy characteristics GlaxoSmithKline Australia, Pty, Ltd (AU) 2013-10-15 US disclosed
EP-1916889-B1 METHODS OF ALTERING POPPY CHARACTERISTICS GLAXOSMITHKLINE AUSTRALIA PTY (AU) 2010-11-03 EP disclosed
EP-1916889-A4 METHODS OF ALTERING POPPY CHARACTERISTICS GLAXOSMITHKLINE AUSTRALIA PTY (AU) 2009-03-11 EP disclosed
US-20080269058-A1 Methods of Altering Poppy Characteristics SUN PHARMACEUTICAL INDUSTRIES (AUSTRALIA) PTY LTD (AU) 2008-10-30 US disclosed
EP-1916889-A1 METHODS OF ALTERING POPPY CHARACTERISTICS Glaxosmithkline Australia PTY Ltd. (AU) 2008-05-07 EP disclosed
WO-2007022561-A1 METHODS OF ALTERING POPPY CHARACTERISTICS GLAXOSMITHKLINE AUSTRALIA PTY LTD (AU) 2007-03-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080269058-A1 Methods of Altering Poppy Characteristics DPP4, PDXK, PNLIP GAA 332/4885MAPT 4164/4885TP53 4515/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.