Sugi Predict

Sugi Predict / Compounds / SCHEMBL3374147

SCHEMBL3374147

SCHEMBL3374147

CN(C(=O)c1cccc(-c2cnc(Nc3ccc(F)c(Cl)c3)nc2-n2ccc(C(F)(F)F)n2)c1)S(C)(=O)=O

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 6/20 0.37
▸ PTK2 Q05397 8/20 0.37
▸ MAPT P10636 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ CSNK1A1 P48729 1/20 0.34
▸ ABL1 P00519 1/20 0.34
▸ RIPK2 O43353 2/20 0.34
▸ NOD2 Q9HC29 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3450657 0.92 SYK (0.39) SYKPTK2MAPTNPSR1CSNK1A1
SCHEMBL3448606 0.89 SYK (0.37) SYKPTK2MAPTNPSR1CSNK1A1
SCHEMBL3452624 0.89 SYK (0.48) SYK
SCHEMBL3374672 0.87 SYK (0.48) SYKMAPTNPSR1
SCHEMBL3374661 0.87 SYK (0.45) SYKPTK2MAPTNPSR1CSNK1A1
SCHEMBL3448235 0.87 SYK (0.49) SYKPTK2MAPTNPSR1CSNK1A1
SCHEMBL3450416 0.83 GPR52 (0.42) SYKPTK2ABL1
SCHEMBL3449562 0.83 MAPT (0.36) SYKPTK2MAPTNPSR1CSNK1A1
SCHEMBL3447449 0.82 SYK (0.37) SYKMAPTNPSR1CSNK1A1
SCHEMBL3451524 0.82 SYK (0.40) SYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11600791-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-03-07 — — US disclosed
EP-3936512-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS Universal Display Corporation (US) 2022-01-12 — — EP disclosed
EP-3424935-B1 IMIDAZOPYRAZINYL CARBENE PHOSPHORESCENT EMITTERS UNIVERSAL DISPLAY CORP (US) 2021-08-11 — — EP disclosed
US-20210050530-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2021-02-18 — — US disclosed
US-10873038-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2020-12-22 — — US disclosed
EP-3313397-B1 PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA MERCK SHARP & DOHME (US) 2020-11-25 — — EP disclosed
US-20190109287-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2019-04-11 — — US disclosed
EP-3424935-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS Universal Display Corporation (US) 2019-01-09 — — EP disclosed
EP-2683728-B1 IRIDIUM COMPLEXES WITH 3-PHENYL-3H-IMIDAZO[4,5-b]PYRIDINE, 3-PHENYL-3H-IMIDAZO[4,5-b]PYRAZINE AND 1-PHENYL-3H-IMIDAZO[4,5-b]PYRIDINE CARBENE LIGANDS USED AS PHOSPHORESCENT EMITTERS IN ORGANIC LIGHT EMITTING DEVICES UNIVERSAL DISPLAY CORP (US) 2018-09-05 — — EP disclosed
US-9972793-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2018-05-15 — — US disclosed
US-8883322-B2 Pyridyl carbene phosphorescent emitters UNIVERSAL DISPLAY CORPORATION (US) 2014-11-11 — — US disclosed
EP-2683728-A2 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS Universal Display Corporation (US) 2014-01-15 — — EP disclosed
WO-2012121936-A2 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS UNIVERSAL DISPLAY CORPORATION (US) 2012-09-13 — — WO disclosed
US-20120228583-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS UNIVERSAL DISPLAY CORPORATION (US) 2012-09-13 — — US disclosed
US-20100137313-A1 HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF ASTRAZENECA AB 2010-06-03 — — US disclosed
US-20100137313-A1 HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF ASTRAZENECA AB 2010-06-03 — — US disclosed
US-20100137313-A1 HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF ASTRAZENECA AB 2010-06-03 — — US disclosed
WO-2010038081-A2 HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF ASTRAZENECA AB (SE) 2010-04-08 — — WO disclosed
WO-2010038081-A2 HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF ASTRAZENECA AB (SE) 2010-04-08 — — WO disclosed
US-20100029643-A1 HETEROCYCLYC SULFONAMIDES HAVING EDG-1 ANTAGONISTIC ACTIVITY ASTRAZENECA AB (SE) 2010-02-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100137313-A1 HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF SDHA, SDHB, UROD SYK 804/4885PTK2 3971/4885MAPT 3947/4885
US-20210050530-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES NUDC, NCL, NDC1 SYK 1309/4885PTK2 2611/4885MAPT 608/4885
US-10873038-B2 Organic electroluminescent materials and devices NUDC, NCL, NDC1 SYK 1309/4885PTK2 2611/4885MAPT 608/4885
US-20100029643-A1 HETEROCYCLYC SULFONAMIDES HAVING EDG-1 ANTAGONISTIC ACTIVITY EDF1, ERLIN1, ECE1 SYK 1784/4885PTK2 3443/4885MAPT 4806/4885
US-20120228583-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS PAICS, PIR, NUDC SYK 1334/4885PTK2 2447/4885MAPT 672/4885
US-20190109287-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES NUDC, NCL, NDC1 SYK 1309/4885PTK2 2611/4885MAPT 608/4885
US-11600791-B2 Organic electroluminescent materials and devices NUDC, NCL, NDC1 SYK 1309/4885PTK2 2611/4885MAPT 608/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.