Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH2 | Q6NS38 | 2/20 | 0.69 |
| ▸ | HPGDS | O60760 | 1/20 | 0.69 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.45 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.44 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4481678 | 0.88 | HPGDS (0.51) | ALKBH2HPGDSKEAP1NFE2L2NPC1 | |
| SCHEMBL30132085 | 0.88 | HPGDS (0.51) | ALKBH2HPGDSKEAP1NFE2L2NPC1 | |
| SCHEMBL5063087 | 0.87 | HPGDS (0.50) | ALKBH2HPGDSKEAP1NFE2L2NPC1 | |
| SCHEMBL7510493 | 0.83 | ALKBH2 (0.71) | ALKBH2HPGDSKEAP1NFE2L2EGLN1 | |
| SCHEMBL2860519 | 0.83 | ALKBH2 (0.71) | ALKBH2HPGDSKEAP1NFE2L2EGLN1 | |
| SCHEMBL70281 | 0.82 | ALKBH2 (1.00) | ALKBH2HPGDSKEAP1NFE2L2EGLN1 | |
| SCHEMBL4796959 | 0.82 | ALKBH2 (0.69) | ALKBH2HPGDSKEAP1NFE2L2EGLN1 | |
| SCHEMBL2854056 | 0.82 | ALKBH2 (0.69) | ALKBH2HPGDSKEAP1NFE2L2EGLN1 | |
| SCHEMBL29544523 | 0.82 | ALKBH2 (0.69) | ALKBH2HPGDSKEAP1NFE2L2EGLN1 | |
| SCHEMBL27680338 | 0.81 | ALKBH2 (0.72) | ALKBH2HPGDSEGLN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029549-B1 | PHENYL-PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORICOID RECEPTOR LIGANDS | GLAXO GROUP LTD (GB) | 2010-11-10 | — | — | EP | disclosed |
| EP-1618092-B1 | ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2010-09-22 | — | — | EP | disclosed |
| US-20100016320-A1 | ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2010-01-21 | — | — | US | disclosed |
| EP-2133348-A1 | Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors | Bristol-Myers Squibb Company (US) | 2009-12-16 | — | — | EP | disclosed |
| US-7605273-B2 | Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-10-20 | — | — | US | disclosed |
| US-20080275092-A1 | ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2008-11-06 | — | — | US | disclosed |
| EP-1618092-A4 | ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2008-08-20 | — | — | EP | disclosed |
| US-7396935-B2 | Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-08 | — | — | US | disclosed |
| EP-1618092-A1 | ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2006-01-25 | — | — | EP | disclosed |
| US-20050159424-A1 | Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2005-07-21 | — | — | US | disclosed |
| WO-2004099156-A1 | ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-11-18 | — | — | WO | disclosed |
| EP-0151866-A2 | Herbicidal pyrazole-(thio)-carboxamides | ELI LILLY AND COMPANY (US) | 1985-08-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275092-A1 | ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | MAPK6, CDK6, GRK6 | ALKBH2 3679/4885HPGDS 2037/4885KEAP1 1644/4885 |
| US-20100016320-A1 | ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | MAPK6, CDK6, GRK6 | ALKBH2 3679/4885HPGDS 2037/4885KEAP1 1644/4885 |
| US-20050159424-A1 | Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors | MAPK6, CDK6, GRK6 | ALKBH2 3679/4885HPGDS 2037/4885KEAP1 1644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.