Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3376775 | 0.86 | GPR119 (0.46) | GPR119SCN9AKCNH2SCN5AACACB | |
| SCHEMBL3374664 | 0.82 | GPR119 (0.48) | GPR119ACACB | |
| SCHEMBL3346772 | 0.82 | GPR119 (0.47) | GPR119KCNH2ACACB | |
| SCHEMBL3373277 | 0.80 | GPR119 (0.48) | GPR119KDM4EPOLBGRM7 | |
| SCHEMBL3343321 | 0.73 | GPR119 (0.55) | GPR119KCNH2 | |
| SCHEMBL3341603 | 0.73 | GPR119 (0.47) | GPR119KCNH2 | |
| SCHEMBL3343984 | 0.73 | ACACB (0.52) | GPR119POLBACACBMAPT | |
| SCHEMBL3342687 | 0.73 | GPR119 (0.52) | GPR119KCNH2ACACB | |
| SCHEMBL3344924 | 0.73 | GPR119 (0.45) | GPR119KCNH2 | |
| SCHEMBL3341593 | 0.72 | GPR119 (0.51) | GPR119KCNH2ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |