SCHEMBL3375185

SCHEMBL3375185

C=CCNc1cccc(N)c1N

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RRM2 P31350 1/20 0.38
CA12 O43570 2/20 0.37
CA1 P00915 2/20 0.37
CA2 P00918 2/20 0.37
CA9 Q16790 2/20 0.37
CA14 Q9ULX7 1/20 0.37
CD44 P16070 1/20 0.34
ALDH1A1 P00352 6/20 0.34
KMT2A Q03164 5/20 0.34
MEN1 O00255 4/20 0.34
MAPT P10636 4/20 0.34
MAPK1 P28482 1/20 0.34
RAB9A P51151 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
HPGD P15428 2/20 0.33
GAA P10253 2/20 0.33
KDM4E B2RXH2 2/20 0.33
LMNA P02545 2/20 0.33
MITF O75030 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL476574 0.84 MAPT (0.42) RRM2CA12CA1CA2CA9
SCHEMBL15928718 0.81 CYP3A4 (0.45) RRM2CA12CA1CA2CA9
SCHEMBL9158033 0.81 ALDH1A1 (0.46) RRM2CA12CA1CA2CA9
SCHEMBL9158714 0.80 RRM2 (0.38) RRM2CA12CA1CA2CA9
SCHEMBL7081554 0.79 CA12 (0.37) RRM2CA12CA1CA2CA9
SCHEMBL8930739 0.78 ALDH1A1 (0.40) RRM2ALDH1A1KMT2AMEN1MAPT
SCHEMBL4784858 0.77 ALDH1A1 (0.44) RRM2CA12CA1CA2CA9
SCHEMBL7694710 0.76 ALDH1A1 (0.40) RRM2CA12CA1CA2CA9
SCHEMBL3380445 0.76 CA12 (0.36) RRM2CA12CA1CA2CA9
SCHEMBL5549248 0.75 RRM2 (0.38) RRM2CA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9943809-B2 Solvent resistant thin film composite membrane and its preparation KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2018-04-17 US claimed
US-20170065937-A1 SOLVENT RESISTANT THIN FILM COMPOSITE MEMBRANE AND ITS PREPARATION KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2017-03-09 US claimed
US-12036515-B2 Thin-film composite membrane and methods of making and using the same THE PENN STATE RESEARCH FOUNDATION (PA) 2024-07-16 US disclosed
US-20210370240-A1 THIN-FILM COMPOSITE MEMBRANE AND METHODS OF MAKING AND USING THE SAME THE PENN STATE RESEARCH FOUNDATION 2021-12-02 US disclosed
EP-3860743-A1 THIN-FILM COMPOSITE MEMBRANE AND METHODS OF MAKING AND USING THE SAME The Penn State Research Foundation (US) 2021-08-11 EP disclosed
WO-2020072594-A1 THIN-FILM COMPOSITE MEMBRANE AND METHODS OF MAKING AND USING THE SAME THE PENN STATE RESEARCH FOUNDATION (US) 2020-04-09 WO disclosed
WO-2019164977-A1 FLUORINATED NUCLEOTIDES AND USES THEREOF Singular Genomics Systems, Inc. (US) 2019-08-29 WO disclosed
US-9943809-B2 Solvent resistant thin film composite membrane and its preparation KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2018-04-17 US disclosed
US-20170065937-A1 SOLVENT RESISTANT THIN FILM COMPOSITE MEMBRANE AND ITS PREPARATION KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2017-03-09 US disclosed
US-7727434-B2 Membranes and methods of treating membranes GENERAL ELECTRIC COMPANY (US) 2010-06-01 US disclosed
US-20070039874-A1 Membranes and methods of treating membranes GENERAL ELECTRIC COMPANY 2007-02-22 US disclosed
US-5693227-A POLYMERIZATION OF MOLECULES HAVING ELECTROPHILIC AND NUCLEOPHILIC SUBSTITUENTS ON THE SAME OR DIFFERENT MOLECULES; REGENERATION OF AMINOPYRIDINE CATALYSTS IONICS, INCORPORATED (US) 1997-12-02 US disclosed
EP-0355364-A2 3,5-Diaminophenyl alkyl amines and their use in hair-dyeing compositions Henkel Kommanditgesellschaft auf Aktien (DE) 1990-02-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12036515-B2 Thin-film composite membrane and methods of making and using the same PORCN, MLEC, FLOT1 RRM2 3891/4885CA12 1547/4885CA1 2322/4885
US-20210370240-A1 THIN-FILM COMPOSITE MEMBRANE AND METHODS OF MAKING AND USING THE SAME PORCN, MLEC, FLOT1 RRM2 3891/4885CA12 1547/4885CA1 2322/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.