Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.76 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28362888 | 0.99 | MAPK14 (0.74) | MAPK14RIPK2PTPN1HTTRAB9A | |
| SCHEMBL1691418 | 0.89 | MAPK14 (0.72) | MAPK14RIPK2HTTRAB9ALMNA | |
| SCHEMBL28236215 | 0.87 | MAPK14 (0.70) | MAPK14RIPK2HTTRAB9ALMNA | |
| SCHEMBL3376508 | 0.85 | MAPK14 (0.56) | MAPK14RIPK2PTPN1RAB9ALMNA | |
| SCHEMBL3376392 | 0.84 | HTT (0.67) | MAPK14RIPK2PTPN1HTTRAB9A | |
| SCHEMBL7826861 | 0.84 | MAPK14 (0.62) | MAPK14RIPK2HTTRAB9ALMNA | |
| SCHEMBL10340642 | 0.83 | MAPK14 (0.58) | MAPK14RIPK2RAB9ALMNASMN1; SMN2 | |
| SCHEMBL1335080 | 0.83 | RIPK2 (0.78) | MAPK14RIPK2PTPN1RAB9ASMN1; SMN2 | |
| SCHEMBL2499070 | 0.83 | RIPK2 (0.56) | MAPK14RIPK2PTPN1HTTRAB9A | |
| SCHEMBL15779140 | 0.83 | MAPK14 (0.57) | MAPK14RAB9ASMN1; SMN2POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108484614-B | Pyrazolo [3,4-d ] pyrimidine-4 (5H) -ketone derivative and preparation method and application thereof | 南开大学 | 2020-01-14 | — | — | CN | disclosed |
| CN-108484614-A | Pyrazolo [3,4-d ] pyrimidine-4 (5H) -ketone derivative and preparation method and application thereof | 南开大学 | 2018-09-04 | — | — | CN | disclosed |
| CN-104902898-B | Diazole lactams | 凯莫森特里克斯股份有限公司 | 2018-02-23 | — | — | CN | disclosed |
| CN-104902898-A | Diazole lactams | CHEMOCENTRYX INC | 2015-09-09 | — | — | CN | disclosed |
| CN-101501003-B | Phenyl-pyrazole derivatives as non-steroidal glucocorticoid receptor ligands | GLAXO GROUP LTD | 2013-05-08 | — | — | CN | disclosed |
| US-20120277279-A1 | Non-Steroidal Glucocorticoid Inhibitors and Their Use in Treating Inflammation, Allergy and Auto-Immune Conditions | GLAXO GROUP LIMITED | 2012-11-01 | — | — | US | disclosed |
| US-8247377-B2 | Non-steroidal glucocorticoid inhibitors and their use in treating inflammation, allergy and auto-immune conditions | GLAXO GROUP LIMITED (GB) | 2012-08-21 | — | — | US | disclosed |
| EP-2029549-B1 | PHENYL-PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORICOID RECEPTOR LIGANDS | GLAXO GROUP LTD (GB) | 2010-11-10 | — | — | EP | disclosed |
| US-20100234441-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-09-16 | — | — | US | disclosed |
| US-20100035926-A1 | PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORTICOID RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2010-02-11 | — | — | US | disclosed |
| US-20100035926-A1 | PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORTICOID RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2010-02-11 | — | — | US | disclosed |
| US-20100035926-A1 | PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORTICOID RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2010-02-11 | — | — | US | disclosed |
| EP-2099766-A1 | PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORTICOID RECEPTOR LIGANDS | Glaxo Group Limited (GB) | 2009-09-16 | — | — | EP | disclosed |
| CN-101501003-A | Phenyl-pyrazole derivatives as non-steroidal glucocorticoid receptor ligands | GLAXO GROUP LTD (GB) | 2009-08-05 | — | — | CN | disclosed |
| WO-2008074814-A1 | PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORTICOID RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008074814-A1 | PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORTICOID RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234441-A1 | NOVEL COMPOUNDS | LTB4R2, TSLP, LTB4R | MAPK14 1393/4885RIPK2 1523/4885PTPN1 3482/4885 |
| US-20100035926-A1 | PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORTICOID RECEPTOR LIGANDS | NR3C1, NR3C2, CYP11B2 | MAPK14 602/4885RIPK2 711/4885PTPN1 593/4885 |
| US-20120277279-A1 | Non-Steroidal Glucocorticoid Inhibitors and Their Use in Treating Inflammation, Allergy and Auto-Immune Conditions | NR3C1, SERPINA6, PTGS1 | MAPK14 530/4885RIPK2 1695/4885PTPN1 331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.