Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PRNP | P04156 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16059176 | 0.89 | LMNA (0.62) | BRAFPIK3CGALDH1A1LMNAGAA | |
| SCHEMBL3376398 | 0.82 | ALDH1A1 (0.50) | BRAFPIK3CGALDH1A1LMNAHPGD | |
| SCHEMBL30361118 | 0.79 | ALDH1A1 (0.50) | BRAFALDH1A1LMNAGAAHPGD | |
| SCHEMBL660801 | 0.79 | ALDH1A1 (0.50) | BRAFALDH1A1LMNAGAAHPGD | |
| SCHEMBL16079488 | 0.78 | MAOB (0.62) | ALDH1A1LMNAGAAHPGDHIF1A | |
| SCHEMBL16029365 | 0.76 | MAOA (0.63) | ALDH1A1LMNAGAAHPGDMAOA | |
| SCHEMBL16079502 | 0.76 | MAOB (0.63) | BRAFPIK3CGALDH1A1LMNAGAA | |
| SCHEMBL17772706 | 0.74 | MAOA (0.74) | ALDH1A1LMNAGAAHPGDHIF1A | |
| SCHEMBL16030391 | 0.74 | MAOA (0.61) | BRAFALDH1A1LMNAGAAMAOA | |
| SCHEMBL16029594 | 0.73 | MAOA (0.60) | BRAFALDH1A1LMNAGAAMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2919788-A1 | METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA | The Johns Hopkins University (US) | 2015-09-23 | — | — | EP | disclosed |
| WO-2010044878-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2010-04-22 | — | — | WO | disclosed |