Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.56 |
| ▸ | RXRB | P28702 | 6/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.56 |
| ▸ | RXRG | P48443 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378347 | 0.80 | RXRA (0.53) | RXRARXRBNR4A2RXRGKDM4E | |
| SCHEMBL5098772 | 0.74 | NR4A2 (0.60) | RXRARXRBNR4A2RXRGKDM4E | |
| Hydrochloric Acid SCHEMBL11714388 | 0.72 | NR4A2 (0.61) | RXRARXRBNR4A2RXRGKDM4E | |
| SCHEMBL7513361 | 0.72 | NR4A2 (0.53) | RXRARXRBNR4A2ALDH1A1MAOB | |
| SCHEMBL11755172 | 0.71 | NR4A2 (0.58) | RXRARXRBNR4A2RXRGKDM4E | |
| SCHEMBL28921929 | 0.70 | RXRA (0.51) | RXRARXRBNR4A2RXRGNPC1 | |
| SCHEMBL8560340 | 0.70 | RXRA (0.46) | RXRARXRBNR4A2RXRGKDM4E | |
| SCHEMBL11754130 | 0.69 | NR4A2 (0.56) | RXRARXRBNR4A2RXRGKDM4E | |
| SCHEMBL15489590 | 0.67 | NPC1 (0.50) | RXRARXRBNR4A2KDM4ENPC1 | |
| SCHEMBL8146050 | 0.67 | NR4A2 (0.83) | RXRARXRBNR4A2RXRGKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966173-B1 | HETEROCYCLIC DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2010-11-17 | — | — | EP | disclosed |
| US-7618991-B2 | Heterocyclic derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2009-11-17 | — | — | US | disclosed |
| US-20080269303-A1 | HETEROCYCLIC DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2008-10-30 | — | — | US | disclosed |
| EP-1966173-A2 | HETEROCYCLIC DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007068815-A2 | HETEROCYCLIC DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269303-A1 | HETEROCYCLIC DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | CYP11B2, CYP11B1, NQO1 | RXRA 724/4885RXRB 899/4885NR4A2 1982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.