Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | FPR2 | P25090 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | CCR9 | P51686 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459398 | 0.84 | SMN1; SMN2 (0.35) | SMN1; SMN2RAB9ANPC1LMNAMAPT | |
| SCHEMBL3378478 | 0.84 | DHFR (0.39) | SMN1; SMN2RAB9ANPC1LMNAMAPT | |
| SCHEMBL3377711 | 0.83 | KMT2A (0.40) | GPR119SMN1; SMN2RAB9ANPC1CNR2 | |
| SCHEMBL3380818 | 0.81 | PDE4D (0.40) | GPR119SMN1; SMN2NPC1CNR2PDE4D | |
| SCHEMBL7905671 | 0.80 | PDE4D (0.39) | RAB9ANPC1LMNAPDE4DCYP3A4 | |
| SCHEMBL3380292 | 0.79 | SLC6A9 (0.37) | GPR119PDE4DCYP3A4CYP2C19PDE4B | |
| SCHEMBL3378344 | 0.78 | ABL1 (0.39) | SMN1; SMN2RAB9APDE4DKMT2AAVPR1B | |
| SCHEMBL3378779 | 0.78 | PIK3CD (0.39) | — | |
| SCHEMBL3377566 | 0.78 | DYRK3 (0.50) | GPR119MAPTPDE4D | |
| SCHEMBL3377163 | 0.76 | SYK (0.36) | PDE4DPDE4BAVPR1BHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |