Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377711 | 0.90 | KMT2A (0.40) | PDE4DPOLQCNR2GPR119GABRA2 | |
| SCHEMBL3377566 | 0.83 | DYRK3 (0.50) | PDE4DPOLQGPR119GABRA2GABRB2 | |
| SCHEMBL3459398 | 0.82 | SMN1; SMN2 (0.35) | PDE4DKMT2AMAPK1NPC1HPGD | |
| SCHEMBL3378478 | 0.82 | DHFR (0.39) | PDE4DMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL3378344 | 0.81 | ABL1 (0.39) | PDE4DMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3378779 | 0.81 | PIK3CD (0.39) | MAPK1 | |
| SCHEMBL3378666 | 0.81 | GPR119 (0.34) | PDE4DCNR2GPR119KMT2ANPC1 | |
| SCHEMBL3380292 | 0.80 | SLC6A9 (0.37) | PDE4DPOLQGPR119MAPK1HPGD | |
| SCHEMBL3465781 | 0.79 | PDE4D (0.63) | PDE4DCNR2MRGPRX4SLC6A3SLC6A2 | |
| SCHEMBL3377783 | 0.79 | PDE4D (0.61) | PDE4DKMT2AALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |