Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378478 | 0.87 | DHFR (0.39) | PDE4DDHFRTLR8DPP4DPP8 | |
| SCHEMBL3377783 | 0.84 | PDE4D (0.61) | PDE4DPDE4BCYP3A4CYP2C19ADORA1 | |
| SCHEMBL3459398 | 0.83 | SMN1; SMN2 (0.35) | PDE4DDHFRMAOBCYP3A4CYP2C19 | |
| SCHEMBL3380430 | 0.82 | MAOB (0.38) | DHFRMAOBCYP2C19DPP4DPP8 | |
| SCHEMBL3433258 | 0.81 | DPP4 (0.38) | PDE4DDHFRMAOBTLR8PDE4B | |
| SCHEMBL3377436 | 0.81 | HDAC6 (0.39) | PDE4DDHFRMAOBCYP3A4TAAR1 | |
| SCHEMBL3377711 | 0.80 | KMT2A (0.40) | PDE4DPDE4BCYP3A4CYP2C19ADORA1 | |
| SCHEMBL3428353 | 0.79 | RAB9A (0.40) | PDE4DDHFRMAOBTAAR1TDO2 | |
| SCHEMBL3380818 | 0.78 | PDE4D (0.40) | PDE4DKDM4EHPGDHTTNPC1 | |
| SCHEMBL7915990 | 0.76 | ADORA1 (0.38) | TLR8CYP3A4ADORA2AADORA1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |