Sugi Predict

Sugi Predict / Compounds / SCHEMBL3378773

SCHEMBL3378773

SCHEMBL3378773

C[SiH](C)Oc1cc(C(C)(C)C)ccc1Br

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 1/20 0.39
▸ CA2 P00918 1/20 0.39
▸ CA9 Q16790 1/20 0.39
▸ ALDH1A1 P00352 6/20 0.35
▸ ALOX15 P16050 2/20 0.35
▸ HSD17B10 Q99714 2/20 0.35
▸ HPGD P15428 1/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ KMT2A Q03164 3/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ NPSR1 Q6W5P4 2/20 0.34
▸ NPC1 O15118 2/20 0.34
▸ RAB9A P51151 2/20 0.34
▸ L3MBTL1 Q9Y468 2/20 0.34
▸ HTT P42858 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.33
▸ MAPT P10636 4/20 0.32
▸ GAA P10253 1/20 0.32
▸ PKM P14618 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1793776 0.98 CA1 (0.38) CA1CA2CA9ALDH1A1ALOX15
SCHEMBL30042825 0.79 MAPT (0.43) CA1CA2CA9ALDH1A1ALOX15
SCHEMBL5737849 0.79 MAPT (0.43) CA1CA2CA9ALDH1A1ALOX15
SCHEMBL6667896 0.78 CA1 (0.39) CA1CA2CA9ALDH1A1ALOX15
SCHEMBL2143927 0.78 CA1 (0.42) CA1CA2CA9ALDH1A1ALOX15
SCHEMBL7355054 0.78 CA1 (0.39) CA1CA2CA9ALDH1A1ALOX15
SCHEMBL1594594 0.78 ALDH1A1 (0.53) CA1CA2CA9ALDH1A1ALOX15
SCHEMBL14142241 0.78 ALDH1A1 (0.44) CA1CA2CA9ALDH1A1ALOX15
SCHEMBL28993182 0.78 CA1 (0.39) CA1CA2CA9ALDH1A1ALOX15
SCHEMBL8119764 0.77 CYP2C19 (0.38) CA1CA2CA9ALDH1A1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110845868-B High-transmission macromolecular green dye, color photosensitive resin composition and color filter 北京鼎材科技有限公司 2022-11-18 — — CN disclosed
CN-110850679-B Macromolecular dye with high transmission and high solubility, color photosensitive resin composition and color filter 北京鼎材科技有限公司 2022-05-03 — — CN disclosed
CN-110845868-A High-transmission macromolecular green dye, color photosensitive resin composition and color filter 北京鼎材科技有限公司 2020-02-28 — — CN disclosed
CN-110850679-A Macromolecular dye with high transmission and high solubility, color photosensitive resin composition and color filter 北京鼎材科技有限公司 2020-02-28 — — CN disclosed
US-9234099-B2 Stimulus-responsive compound, deformable material, and actuator SEIKO EPSON CORPORATION (JP) 2016-01-12 — — US disclosed
US-20150191596-A1 STIMULUS-RESPONSIVE COMPOUND, DEFORMABLE MATERIAL, AND ACTUATOR SEIKO EPSON CORPORATION (JP) 2015-07-09 — — US disclosed
EP-1401433-B1 AZOLE ACID DERIVATIVES, ALONE OR IN COMBINATION, FOR TREATING DIABETES AND DYSLIPIDEMIAS; AND FOR TREATING MALIGNANT DISEASES BRISTOL MYERS SQUIBB CO (US) 2010-11-10 — — EP disclosed
US-7452907-B2 Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method BRISTOL-MYERS SQUIBB COMPANY (US) 2008-11-18 — — US disclosed
US-7105556-B2 Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method BRISTOL-MYERS SQUIBB COMPANY (US) 2006-09-12 — — US disclosed
US-20060189598-A1 Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method CHENG PETER T 2006-08-24 — — US disclosed
US-5532243-A SIGMA RECEPTOR ANTAGONISTS; SIDE EFFECT REDUCTION THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1996-07-02 — — US disclosed
EP-0630370-A1 FUNGICIDAL OXAZOLIDINONES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1994-12-28 — — EP disclosed
US-5296479-A Treating physiological or drug-induced psychosis or dyskinesia THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-03-22 — — US disclosed
US-5266572-A Antipsychotic 1-cycloalkylpiperidines THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-11-30 — — US disclosed
WO-1993018016-A1 FUNGICIDAL OXAZOLIDINONES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-09-16 — — WO disclosed
US-5243048-A Treatment of drug-induced or physiological psychosis or dyskinesia; side effect reduction THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-09-07 — — US disclosed
WO-1993016050-A1 ANTIPSYCHOTIC NITROGEN-CONTAINING BICYCLIC COMPOUNDS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-08-19 — — WO disclosed
EP-0490962-A1 ANTIPSYCHOTIC 1-CYCLOALKYLPIPERIDINES THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1992-06-24 — — EP disclosed
US-5109002-A ANTIPSYCHOTIC 1-CYCLOALKYLPIPERIDINES DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1992-04-28 — — US disclosed
WO-1991003243-A1 ANTIPSYCHOTIC 1-CYCLOALKYLPIPERIDINES THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1991-03-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060189598-A1 Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method GPR119, LIPC, GLP1R CA1 3539/4885CA2 2185/4885CA9 2030/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.