Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 4/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9262125 | 0.75 | AXL (0.41) | GABRG2GABRB3GABRA1GABRA2GSK3A | |
| SCHEMBL7437667 | 0.74 | PRKAB2 (0.51) | GSK3BALDH1A1MAPK1HSD17B10PPARG | |
| SCHEMBL7445604 | 0.74 | KCNN3 (0.66) | ALDH1A1MAPK1HSD17B10PPARGCLK4 | |
| SCHEMBL7438857 | 0.73 | GSK3B (0.48) | GABRG2GABRB3GABRA1GABRA2GSK3A | |
| SCHEMBL7438169 | 0.73 | AXL (0.47) | GABRG2GABRB3GABRA1GABRA2GSK3A | |
| SCHEMBL7320243 | 0.73 | PPARG (0.47) | GSK3AGSK3BAXLFLT3MERTK | |
| SCHEMBL7441417 | 0.72 | MEN1 (0.49) | ALDH1A1MAPK1HSD17B10MAPTCLK4 | |
| SCHEMBL9262231 | 0.71 | PPARG (0.46) | GSK3AGSK3BAXLFLT3MERTK | |
| SCHEMBL7435705 | 0.71 | KCNN3 (0.46) | PPARG | |
| SCHEMBL30904901 | 0.71 | KDM4E (0.44) | KDM4EHPGDALDH1A1GLAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | claimed |