Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN3 | Q9UGI6 | 5/20 | 0.46 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.46 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CCNH | P51946 | 1/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 6/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437667 | 0.91 | PRKAB2 (0.51) | KCNN3KCNN1KCNN2PRKAB2PRKAG1 | |
| SCHEMBL7441417 | 0.84 | MEN1 (0.49) | KCNN3KCNN1KCNN2CDK2CCNE1 | |
| SCHEMBL7445604 | 0.84 | KCNN3 (0.66) | KCNN3KCNN1KCNN2CDK2CCNE1 | |
| SCHEMBL7442662 | 0.80 | KCNN3 (0.45) | KCNN3KCNN1KCNN2CCNT1CDK7 | |
| SCHEMBL7435695 | 0.80 | DPP4 (0.39) | CCNT1CDK7CDK9CCNHCDK2 | |
| SCHEMBL7449214 | 0.79 | CDK2 (0.46) | CDK2CCNE1PPARGAGTR1 | |
| SCHEMBL7447428 | 0.78 | CYP1A2 (0.44) | KCNN3KCNN1KCNN2CDK9PRKAG1 | |
| SCHEMBL7445484 | 0.78 | PRKAB2 (0.42) | KCNN3KCNN1KCNN2CDK7CDK9 | |
| SCHEMBL7447205 | 0.76 | CDK2 (0.46) | CDK2ACHECCNE1PPARG | |
| SCHEMBL7447111 | 0.76 | GAA (0.51) | CDK2PPARGMYCWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |