Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3376594 | 0.89 | HRH3 (0.50) | HRH3MEN1KMT2AADRB2TSHR | |
| SCHEMBL3376038 | 0.88 | ALDH1A1 (0.52) | HRH3POLBKCNH2MCHR1ACHE | |
| SCHEMBL3381187 | 0.85 | HRH3 (0.47) | HRH3MEN1KMT2AADRB2TSHR | |
| SCHEMBL4646695 | 0.85 | HRH3 (0.40) | HRH3MEN1KMT2APOLBKCNH2 | |
| SCHEMBL3377442 | 0.83 | ADRB2 (0.49) | HRH3MEN1KMT2AADRB2KCNH2 | |
| SCHEMBL3379985 | 0.83 | HRH3 (0.55) | HRH3MEN1KMT2AADRB2TSHR | |
| SCHEMBL3379325 | 0.83 | HRH3 (0.55) | HRH3MEN1KMT2AADRB2TSHR | |
| SCHEMBL4646535 | 0.82 | MEN1 (0.52) | HRH3MEN1KMT2APOLB | |
| SCHEMBL3376675 | 0.81 | HRH3 (0.51) | HRH3MEN1KMT2AADRB2KCNH2 | |
| SCHEMBL3377637 | 0.79 | MEN1 (0.45) | HRH3MEN1KMT2APOLBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |