SCHEMBL3385477

SCHEMBL3385477

Cc1cc(-c2ccn3c(-c4ccc(CC(=O)Nc5cc(C(C)(C)C)ccn5)c(F)c4)cnc3c2)cc(C)n1

nearest known ligand 0.41

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FGFR3 P22607 19/20 0.41
KDR P35968 17/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3386163 0.94 WNT3A (0.42) FGFR3KDR
SCHEMBL3382504 0.91 KDR (0.47) FGFR3KDR
SCHEMBL3178478 0.89 FGFR3 (0.52) FGFR3KDR
SCHEMBL3383226 0.88 PSEN1 (0.45) FGFR3KDR
SCHEMBL3189267 0.87 KDR (0.45) FGFR3KDR
SCHEMBL3383240 0.87 FGFR3 (0.49) FGFR3KDR
SCHEMBL3381930 0.86 KDR (0.39) FGFR3KDR
SCHEMBL3383499 0.85 KDR (0.46) FGFR3KDR
SCHEMBL3386417 0.83 FGFR3 (0.54) FGFR3KDR
SCHEMBL3385818 0.83 KDR (0.49) FGFR3KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1904494-B1 IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS LILLY CO ELI (US) 2010-12-01 EP disclosed