Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 11/20 | 0.46 |
| ▸ | WNT3A | P56704 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382504 | 0.93 | KDR (0.47) | KDRFGFR3WNT3AFLT3PIK3CA | |
| SCHEMBL3384812 | 0.91 | KDR (0.45) | KDRFGFR3WNT3AFLT3PIK3CA | |
| SCHEMBL3385352 | 0.88 | WNT3A (0.49) | KDRFGFR3WNT3A | |
| SCHEMBL3382979 | 0.88 | FGFR3 (0.48) | KDRFGFR3WNT3A | |
| SCHEMBL3386163 | 0.87 | WNT3A (0.42) | KDRFGFR3WNT3A | |
| SCHEMBL3385818 | 0.85 | KDR (0.49) | KDRFGFR3ABL1BCRDDR1 | |
| SCHEMBL3385477 | 0.85 | FGFR3 (0.41) | KDRFGFR3 | |
| SCHEMBL3189267 | 0.84 | KDR (0.45) | KDRFGFR3WNT3A | |
| SCHEMBL3383482 | 0.83 | KDR (0.49) | KDRFGFR3PIK3CAMTORABL1 | |
| SCHEMBL3186484 | 0.83 | KDR (0.49) | KDRFGFR3ABL1BCRDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |