Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
| ▸ | CKS1B | P61024 | 1/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380520 | 0.61 | MAPT (0.37) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL4023574 | 0.60 | MAPT (0.62) | ATMMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL246399 | 0.59 | ADORA2A (0.45) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL20421676 | 0.58 | ALDH1A1 (0.54) | ATMMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4026288 | 0.58 | IMPDH2 (0.49) | ATMKDM4EALDH1A1MAPTCHUK | |
| SCHEMBL16508205 | 0.58 | IMPDH2 (0.42) | ATMKMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL20436327 | 0.57 | ALDH1A1 (0.57) | KMT2AKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL247776 | 0.57 | NPC1 (0.40) | KDM4EALDH1A1SMN1; SMN2IMPDH2 | |
| SCHEMBL10609908 | 0.57 | KDM4E (0.54) | KDM4EALDH1A1MAPT | |
| SCHEMBL13286792 | 0.56 | ATM (0.54) | ATMMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012000595-A1 | 2,4- DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER | MERCK PATENT GMBH (DE) | 2012-01-05 | — | — | WO | disclosed |