Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | GALK1 | P51570 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5173798 | 0.80 | ALDH1A1 (0.54) | MAPTKDM4EALDH1A1HPGDCASP6 | |
| SCHEMBL16508198 | 0.76 | CASP6 (0.44) | MAPTKDM4EALDH1A1HPGDCHUK | |
| SCHEMBL4023574 | 0.75 | MAPT (0.62) | MAPTKDM4EALDH1A1GALK1ATM | |
| SCHEMBL16508209 | 0.73 | IMPDH2 (0.53) | IMPDH2MAPTKDM4EALDH1A1CASP6 | |
| SCHEMBL5657826 | 0.72 | RXFP1 (0.45) | MAPTKDM4EALDH1A1HPGDCHUK | |
| SCHEMBL4026288 | 0.70 | IMPDH2 (0.49) | IMPDH2MAPTKDM4EALDH1A1CHUK | |
| SCHEMBL20072220 | 0.70 | ALDH1A1 (0.47) | IMPDH2MAPTKDM4EALDH1A1CHUK | |
| SCHEMBL1637363 | 0.69 | ALDH1A1 (0.55) | IMPDH2MAPTALDH1A1HPGDCHUK | |
| SCHEMBL30418934 | 0.69 | ALDH1A1 (0.55) | IMPDH2MAPTALDH1A1HPGDCHUK | |
| SCHEMBL4019913 | 0.69 | CHUK (0.45) | MAPTKDM4EALDH1A1CHUKGALK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110294789-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | AMNESTIX, INC. | 2011-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294789-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | ROCK1, IRAK1, ROCK2 | IMPDH2 2141/4885MAPT 704/4885KDM4E 590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.