Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 13/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3186146 | 0.94 | FGFR3 (0.36) | KDRFGFR3RIPK2CTSCRIPK3 | |
| SCHEMBL3186140 | 0.94 | FGFR3 (0.36) | KDRFGFR3RIPK2CTSCRIPK3 | |
| SCHEMBL3381301 | 0.89 | KDR (0.35) | KDRFGFR3CTSCNTRK1 | |
| SCHEMBL3188986 | 0.89 | RIPK3 (0.38) | KDRFGFR3RIPK3 | |
| SCHEMBL3383109 | 0.87 | KDR (0.35) | KDRFGFR3CTSC | |
| SCHEMBL3383495 | 0.86 | KDR (0.37) | KDRFGFR3 | |
| SCHEMBL3384199 | 0.86 | FGFR3 (0.39) | KDRFGFR3 | |
| SCHEMBL3382504 | 0.86 | KDR (0.47) | KDRFGFR3NTRK1 | |
| SCHEMBL3386163 | 0.85 | WNT3A (0.42) | KDRFGFR3 | |
| SCHEMBL3381930 | 0.85 | KDR (0.39) | KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |