Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 10/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | NEK2 | P51955 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385250 | 0.89 | FLT3 (0.47) | KDRFGFR3DDR1RETCSF1R | |
| SCHEMBL3385219 | 0.88 | KDR (0.53) | KDRFGFR3DDR1 | |
| SCHEMBL3385496 | 0.86 | KDR (0.50) | KDRFGFR3RETNTRK1GSK3B | |
| SCHEMBL3195980 | 0.85 | RET (0.60) | KDRFGFR3DDR1RETABL1 | |
| SCHEMBL3417117 | 0.82 | WNT3A (0.49) | KDRFGFR3 | |
| SCHEMBL3381109 | 0.79 | RET (0.56) | KDRFGFR3RET | |
| SCHEMBL3384065 | 0.79 | KDR (0.52) | KDRFGFR3CSF1RFLT1 | |
| SCHEMBL3384190 | 0.79 | KDR (0.62) | KDRFGFR3NTRK1 | |
| SCHEMBL31481233 | 0.79 | KDR (0.47) | KDRRETCSF1RPDPK1KIT | |
| SCHEMBL3385818 | 0.78 | KDR (0.49) | KDRFGFR3DDR1ABL1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |